91037-75-1
中文名称
glycyl-arginyl-glycyl-aspartyl-seryl-proline
英文名称
glycyl-arginyl-glycyl-aspartyl-seryl-proline
CAS
91037-75-1
分子式
C22H37N9O10
分子量
587.58
MOL 文件
91037-75-1.mol
更新日期
2024/05/31 09:04:35
91037-75-1 结构式
基本信息
中文别名
合成线性RGD肽甘氨酰-精氨酰-甘氨酰-天冬氨酰-丝氨酰-脯氨酸
英文别名
glycyl-arginyl-glycyl-aspartyl-seryl-prolineGlycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-proline
L-Proline, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-
所属类别
生物化工：抑制剂常见问题列表
用途
GRGDSP可用于修饰心血管植入物表面，如血管移植物，促进内皮化。
生物活性
GRGDSP 是一种合成的线性RGD肽，是一种整联蛋白 (integrin) 抑制剂。靶点
Integrin
体外研究
It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization.