泮考必利
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- CAS号:
- 121650-80-4
- 英文名:
- Pancopride
- 英文别名:
- LAS 30451;Pancoprida;Pancopride;Pancopridum;Pancopridum [inn-latin];Pancoprida [inn-spanish];Benzamide, 4-amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-(cyclopropylmethoxy)-
- 中文名:
- 泮考必利
- 中文别名:
- 泮考必利;化合物 T16433
- CBNumber:
- CB01179437
- 分子式:
- C18H24ClN3O2
- 分子量:
- 349.86
- MOL File:
- 121650-80-4.mol
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泮考必利化学性质
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沸点:
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502.3±50.0 °C(Predicted)
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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13.56±0.20(Predicted)
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泮考必利性质、用途与生产工艺
Pancopride 是一种新型有效的选择性 5-HT3 受体拮抗剂。
Pancopride is a new potent and selective 5-HT
3
receptor antagonist, orally and parenterally effective against cytotoxic drug-induced emesis. Pancopride displayed high affinity (K
i
=0.40 nM) for [
3
H]GR65630-labelled 5-HT
3
recognition sites in membranes from the cortex of rat brains.
Pancopride antagonizes 5-HT-induced bradycardia in anaesthetized rats when administered i.v. 5 min (ID
50
=0.56 μg/kg) or p.o. 60 min (ID
50
=8.7 μg/kg) before 5-HT challenge. A single oral dose (10 μg/kg) of Pancopride produced a significant inhibition of the bradycardic reflex over an 8-h period. Pancopride dose dependently inhibited the number of vomiting episodes and delayed the onset of vomiting induced by cisplatin in dogs (ID
50
=3.6 μg/kg i.v. and 7.1 μg/kg p.o.). Pancopride inhibits vomiting induced by cisplatin in dogs and is also effective in blocking mechloretamine- and dacarbazine-induced emesis lacking any antidopaminergic activity. Pancopride stimulates gastric emptying of glass beads in the rat (DE
50
=0.032 mg/kg p.o.). Pancopride (1 mg/kg i.p.) also reverses cisplatin induced slowing of gastric emptying in the rat.
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121650-80-4, 泮考必利 相关搜索:
- 化合物 T16433
- 泮考必利
- 121650-80-4
- LAS 30451
- Benzamide, 4-amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-(cyclopropylmethoxy)-
- Pancopridum [inn-latin]
- Pancopridum
- Pancoprida [inn-spanish]
- Pancoprida
- Pancopride