RECILISIB 钠盐
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- CAS号:
- 334969-03-8
- 英文名:
- 4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID
- 英文别名:
- ON01210;Recilisib;Recilisib sodium;Recilisib sodium salt;Recilisib sodium(ON01210);4-Chlorobenzyl-4-carboxystyryl sulfone;4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID;Benzoic acid, 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]ethenyl]-;PI3K,ON-01210,PKB,Akt,ON01210,Recilisib,Protein kinase B,inhibit,Phosphoinositide 3-kinase,Inhibitor
- 中文名:
- RECILISIB 钠盐
- 中文别名:
- RECILISIB 钠盐;磷酸氢二(2-乙氧基乙基);(E)-4-(2-((4-氯苄基)磺酰基)乙烯基)苯甲酸
- CBNumber:
- CB01501926
- 分子式:
- C16H13ClO4S
- 分子量:
- 336.79
- MOL File:
- 334969-03-8.mol
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RECILISIB 钠盐化学性质
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沸点:
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607.8±55.0 °C(Predicted)
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密度:
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1.423±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 35.71 mg/mL (106.03 mM)
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酸度系数(pKa):
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4.00±0.10(Predicted)
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RECILISIB 钠盐性质、用途与生产工艺
Recilisib 是一种辐射防护剂，可以激活细胞中 AKT 和 PI3K 的活性。
Recilisib Sodium (up to 50 µM) shows a normal distribution of cells throughout the cell cycle, with a slight reduction in the number of cells in S-phase at 50 µM. Continuous exposure of Recilisib Sodium (100 µM) does not result in cell death. Recilisib Sodium does not inhibit the ability of human bone marrow to form colonies in methylcellulose at either timepoint. Recilisib Sodium treatment does not inhibit the colony forming potential of human bone marrow cells. Recilisib Sodium provides dose dependent protection of human bone marrow cells at all three doses of IR. Recilisib Sodium activates the phosphorylation of AKT and GSK3α/β in HFL cells. Recilisib Sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib Sodium treatment in combination with radiation alters the MAPK signaling pathway.
Recilisib Sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib Sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure.
RECILISIB 钠盐
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101625 | Recilisib | | 1 mg | 500元 |
| 2024/04/30 | HY-101625 | RECILISIB 钠盐
Recilisib | 334969-03-8 | 5mg | 1100元 |
334969-03-8, RECILISIB 钠盐 相关搜索:
- (E)-4-(2-((4-氯苄基)磺酰基)乙烯基)苯甲酸
- 磷酸氢二(2-乙氧基乙基)
- RECILISIB 钠盐
- 334969-03-8
- PI3K,ON-01210,PKB,Akt,ON01210,Recilisib,Protein kinase B,inhibit,Phosphoinositide 3-kinase,Inhibitor
- Benzoic acid, 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]ethenyl]-
- 4-Chlorobenzyl-4-carboxystyryl sulfone
- ON01210
- Recilisib sodium(ON01210)
- Recilisib sodium
- Recilisib
- 4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID
- Recilisib sodium salt