4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

生物活性体外研究

CAS号:: 174264-46-1

英文名:: 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

英文别名:: Sulfamic Acid Impurity 6;4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;6-Hydroxy-4'-tert-butyldiMethylsylyl Raloxifene;4a€-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;[2-[4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]Methanone;Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-

中文名:

中文别名:

CBNumber:: CB01872789

分子式:: C34H41NO4SSi

分子量:: 587.84414

MOL File:: 174264-46-1.mol

化学性质安全信息用途供应商 12

4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene化学性质

储存条件:: Refrigerator

溶解度:: Acetone, Chloroform, Dichloromethane, Ethanol, Methanol

形态:: Solid

颜色:: Yellow

CAS 数据库:: 174264-46-1

安全信息

4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene性质、用途与生产工艺

生物活性

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) 是一种Raloxifene 与叔丁基二甲基甲硅烷基氯的反应产物。4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 可用于合成 Raloxifene 6-glucuronide。

The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide.

4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 上下游产品信息

上游原料

下游产品

4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 生产厂家

全球有 12家供应商 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
北京百灵威科技有限公司	010-82848833 400-666-7788	jkinfo@jkchemical.com	中国	96815	76
凯试（上海）科技有限公司	021-50135380	shchemsky@sina.com	中国	32344	50
上海陶素生化科技有限公司	021-33632979	info@tsbiochem.com	中国	8073	58
深圳聚合生化科技有限公司	+86-400-002-6226 13028896684	sales@rrkchem.com	中国	55954	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing1@energy-chemical.com	中国	44843	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
湖北国云福瑞科技有限公司	18162595016	3287908757@qq.com	中国	10012	58
Carbosynth		sales@carbosynth.com	英国	6018	58

174264-46-1, 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 相关搜索:

雷洛昔芬

Pharmaceuticals, Intermediates & Fine Chemicals
Pharmaceuticals
Intermediates & Fine Chemicals
C34H41NO4SSi
174264-46-1
Sulfamic Acid Impurity 6
Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
4a€-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
6-Hydroxy-4'-tert-butyldiMethylsylyl Raloxifene
[2-[4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]Methanone