PAC-1-d8
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- CAS号:
- 1287241-26-2
- 英文名:
- PAC-1-d8
- 英文别名:
- PAC-1-d8;[2H8]-PAC-1;YQNRVGJCPCNMKT-SRNXAORYSA-N
- 中文名:
- PAC-1-d8
- 中文别名:
- [2H8]-PAC-1
- CBNumber:
- CB02511333
- 分子式:
- C23H28N4O2
- 分子量:
- 392.49402
- MOL File:
- 1287241-26-2.mol
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PAC-1-d8化学性质
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溶解度:
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soluble in DMSO, Methanol
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形态:
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Solid
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颜色:
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Off-White
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PAC-1-d8性质、用途与生产工艺
用途
Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is th
e circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.
92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
PAC-1-d8
上下游产品信息
上游原料
下游产品
1287241-26-2, PAC-1-d8 相关搜索:
- Pharmaceuticals
- Isotope Labelled Compounds
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
- C23H20D8N4O2
- [2H8]-PAC-1
- 1287241-26-2
- [2H8]-PAC-1
- YQNRVGJCPCNMKT-SRNXAORYSA-N
- PAC-1-d8