886563-25-3
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- CAS号:
- 886563-25-3
- 英文名:
- ZK-261991
- 英文别名:
- ZK-991;ZK 991;ZK-261991;ZK261991(ZK991);ZK 261991,ZK261991;ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991;Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-
- 中文名:
- 886563-25-3
- 中文别名:
- 化合物 T13402
- CBNumber:
- CB02628541
- 分子式:
- C24H25N7O2
- 分子量:
- 443.5
- MOL File:
- 886563-25-3.mol
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886563-25-3化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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886563-25-3性质、用途与生产工艺
ZK-261991 是一种可口服的 VEGFR 酪氨酸酶抑制剂，抑制 VEGFR-2 活性的 IC50 值为 5 nM。
ZK-261991 inhibits cellular receptor autophosphorylation in KDR-PAECs with an IC
50
of 2 nM. ZK991 inhibits VEGFR-3 autophosphorylation concentration dependently with an IC
50
of 20 nM.
ZK991 results in a significantly reduced recruitment of CD11b
+
and LYVE-1
+
cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation.
886563-25-3
上下游产品信息
上游原料
下游产品
886563-25-3, 886563-25-3 相关搜索:
- 化合物 T13402
- 886563-25-3
- ZK 261991,ZK261991
- Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-
- ZK-991
- ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991
- ZK 991
- ZK261991(ZK991)
- ZK-261991