巴佛洛霉素C 1
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- CAS号:
- 88979-61-7
- 英文名:
- BAFILOMYCIN C1
- 英文别名:
- L-681110A1;BAFILOMYCIN C1;Antibiotic L-681110A1;Bafilomycin C-1,Bafilomycin C1;2-Demethyl-2-methoxy-24-methylhygrolidin;Bafilomycin C1, from Streptomyces griseus;2-Butenedioic acid (2E)-, 1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl] ester
- 中文名:
- 巴佛洛霉素C 1
- 中文别名:
- 巴菲霉素C1;巴弗洛霉素C1;巴伐洛霉素 C1;巴佛洛霉素C 1;化合物 T22598
- CBNumber:
- CB0320023
- 分子式:
- C39H60O12
- 分子量:
- 720.89
- MOL File:
- 88979-61-7.mol
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巴佛洛霉素C 1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/ml; Methanol: 5 mg/ml
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形态:
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White to light-brown solid.
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颜色:
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Yellow
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巴佛洛霉素C 1性质、用途与生产工艺
Bafilomycin C1 是从链霉菌中分离得到的大环内酯类抗生素 (antibiotic)。Bafilomycin C1 是一种有效的、特异性的、可逆的 vacuolar-type H+-ATPases 抑制剂。Bafilomycin C1 抑制革兰氏阳性菌 (bacteria) 和真菌 (fungi) 的生长。Bafilomycin C1 可诱导细胞凋亡 (apoptosis)，可用于肝细胞癌 (HCC) 的研究。
Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner.Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells.Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle.
Cell Viability Assay
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Cell Line:
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SMMC7721 cell and HepG2 cell
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Concentration:
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0.33 μM, 1.1 μM, and 3.3 μM for SMMC77211.1 μM, 3.3 μM, and 10.0 μM for HepG2
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Incubation Time:
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6 days
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Result:
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Retarded the cell growth.
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Western Blot Analysis
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Cell Line:
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SMMC7721 cells
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Concentration:
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3.3 μM
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Incubation Time:
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24 hours
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Result:
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Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21.
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Apoptosis Analysis
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Cell Line:
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SMMC7721 and HepG2 cells
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Concentration:
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3.3 μM; 10 μM
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Incubation Time:
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24 hours
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Result:
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Induced apoptosis in SMMC7721 and HepG2 cells.
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Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model.
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Animal Model:
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BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×10
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cells/100 μL)
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Dosage:
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0.2 mg/kg
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Administration:
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Subcutaneous injection; 20 days
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Result:
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Suppressed tumor growth of SMMC7721 tumor xenografts.
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巴佛洛霉素C 1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-130173 | 巴佛洛霉素C 1
Bafilomycin C1 | 88979-61-7 | 1mg | 3500元 |
| 2024/04/30 | HY-130173 | 巴佛洛霉素C 1
Bafilomycin C1 | 88979-61-7 | 5 mg | 9800元 |
88979-61-7, 巴佛洛霉素C 1 相关搜索:
- 微生物代谢物
- C39H60O12
- 化合物 T22598
- 巴菲霉素C1
- 巴弗洛霉素C1
- 巴伐洛霉素 C1
- 巴佛洛霉素C 1
- 88979-61-7
- Bafilomycin C-1,Bafilomycin C1
- 2-Butenedioic acid (2E)-, 1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl] ester
- Bafilomycin C1, from Streptomyces griseus
- BAFILOMYCIN C1
- L-681110A1
- Antibiotic L-681110A1
- 2-Demethyl-2-methoxy-24-methylhygrolidin