IITZ-01
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- CAS号:
- 1807988-47-1
- 英文名:
- IITZ-01
- 英文别名:
- IITZ-01;CS-2857;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
- 中文名:
- IITZ-01
- 中文别名:
- 化合物IITZ-01;N2-(4-(1H-苯并[D]咪唑-2-基)苯基)-N4-(4-氟苯基)-6-吗啉代-1,3,5-三嗪-2,4-二胺
- CBNumber:
- CB04668033
- 分子式:
- C26H23FN8O
- 分子量:
- 482.51
- MOL File:
- 1807988-47-1.mol
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IITZ-01化学性质
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沸点:
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747.0±70.0 °C(Predicted)
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密度:
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1.420±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
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酸度系数(pKa):
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11.55±0.10(Predicted)
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IITZ-01性质、用途与生产工艺
IITZ-01 是一个具有抗肿瘤活性的、有效的亲溶酶体的自噬抑制剂，其对 PI3Kγ 的 IC50 值为 2.62 μM。
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PI3Kγ
2.62 μM (IC
50
)
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Autophagy
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IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.
Western Blot Analysis
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Cell Line:
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Triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453).
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Concentration:
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0-2 μM.
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Incubation Time:
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24 hours.
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Result:
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Enhanced autophagosomes formation as indicated by increased expression of LC3-II levels.
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IITZ-01 (45 mg/kg, i.p. every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.
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Animal Model:
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MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr-Foxn
nu
BALB/c female nude mice.
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Dosage:
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45 mg/kg.
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Administration:
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Intraperitoneal every alternate day for 4 weeks.
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Result:
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Inhibited average breast tumor growth when compared with control from third day of treatment.
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IITZ-01
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112897 | IITZ-01
IITZ-01 | 1807988-47-1 | 5mg | 700元 |
| 2024/04/30 | HY-112897 | IITZ-01
IITZ-01 | 1807988-47-1 | 10mM * 1mLin DMSO | 740元 |
1807988-47-1, IITZ-01 相关搜索:
- API
- 高端化学
- C26H23FN8O
- 化合物IITZ-01
- N2-(4-(1H-苯并[D]咪唑-2-基)苯基)-N4-(4-氟苯基)-6-吗啉代-1,3,5-三嗪-2,4-二胺
- 1807988-47-1
- Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K
- N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
- 1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
- CS-2857
- AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01
- Autophagy inhibitor IITZ-01
- AUTOPHAGY INHIBITOR;IITZ 01;IITZ01
- IITZ-01