DT2216
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- CAS号:
- 2365172-42-3
- 英文名:
- DT2216
- 英文别名:
- DT2216;DT2216,DT-2216;(2S,4R)-1-[(2S)-2-[[7-[4-[(3R)-3-[4-[[4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-cyclohexen-1-yl]methyl]piperazin-1-yl]benzoyl]sulfamoyl]-2-(trifluoromethylsulfonyl)anilino]-4-phenylsulfanyl-butyl]piperazin-1-yl]-7-oxo-heptanoyl]amino]-3,3-dimethyl-butanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
- 中文名:
- DT2216
- 中文别名:
- 化合物DT2216;(2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-氯-4,4-二甲基-3,4,5,6-四氢-[1,1'-联苯]-2-基)甲基)哌嗪-1-基)苯甲酰基)氨磺酰基)-2-((三氟甲基)磺酰基)苯基)氨基)-4-(苯硫基)丁基)哌嗪-1-基)-7-氧代庚酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-((S)-1-(4-(4-甲基噻唑-5-基)苯基)乙基)吡咯烷-2-甲酰胺
- CBNumber:
- CB07247428
- 分子式:
- C77H96ClF3N10O10S4
- 分子量:
- 1542.36
- MOL File:
- 2365172-42-3.mol
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DT2216化学性质
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密度:
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1.39±0.1 g/cm3(Predicted)
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溶解度:
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DMSO:20.0(Max Conc. mg/mL);12.97(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);6.48(Max Conc. mM)-
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酸度系数(pKa):
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4.60±0.10(Predicted)
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DT2216性质、用途与生产工艺
DT2216 是一种基于PROTAC技术的 BCL-XL 的强效选择性降解剂。DT2216 抑制各种BCL-XL依赖性白血病和癌细胞,但对血小板的毒性较小。
DT2216
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2022/04/29 | HY-130604 | DT2216 DT2216 | 2365172-42-3 | 5mg | 11800元 |
2022/04/29 | HY-130604 | DT2216 DT2216 | 2365172-42-3 | 10mg | 19500元 |
2365172-42-3, DT2216 相关搜索:
- 小分子API
- C77H96ClF3N10O10S4
- (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-氯-4,4-二甲基-3,4,5,6-四氢-[1,1'-联苯]-2-基)甲基)哌嗪-1-基)苯甲酰基)氨磺酰基)-2-((三氟甲基)磺酰基)苯基)氨基)-4-(苯硫基)丁基)哌嗪-1-基)-7-氧代庚酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-((S)-1-(4-(4-甲基噻唑-5-基)苯基)乙基)吡咯烷-2-甲酰胺
- 化合物DT2216
- 2365172-42-3
- (2S,4R)-1-[(2S)-2-[[7-[4-[(3R)-3-[4-[[4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-cyclohexen-1-yl]methyl]piperazin-1-yl]benzoyl]sulfamoyl]-2-(trifluoromethylsulfonyl)anilino]-4-phenylsulfanyl-butyl]piperazin-1-yl]-7-oxo-heptanoyl]amino]-3,3-dimethyl-butanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
- (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
- DT2216,DT-2216
- DT2216