153437-55-9
|
|
|
- CAS号:
- 153437-55-9
- 英文名:
- 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
- 英文别名:
- WHI-P180 HCl;Janex 3 hydrochloride;WHI-P180, HYDROCHLORIDE;4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL;4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL;4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride
- 中文名:
- 153437-55-9
- 中文别名:
- WHI-P180盐酸盐;化合物 WHI-P180 HYDROCHLORIDE
- CBNumber:
- CB0787091
- 分子式:
- C16H16ClN3O3
- 分子量:
- 333.76954
- MOL File:
- Mol file
|
|
|
153437-55-9化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Powder
-
|
153437-55-9性质、用途与生产工艺
WHI-P180 (Janex 3)是多种激酶抑制剂；抑制 RET，KDR 和 EGFR 的IC50 值分别为5 nM，66 nM 和4 μM。
|
EGFR
4 μM (IC
50
)
|
KDR
66 nM (IC
50
)
|
RET
5 nM (IC
50
)
|
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
153437-55-9
上下游产品信息
上游原料
下游产品
153437-55-9, 153437-55-9 相关搜索:
- 高端化学
- 化合物 WHI-P180 HYDROCHLORIDE
- WHI-P180盐酸盐
- 153437-55-9
- 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
- 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride
- Janex 3 hydrochloride
- WHI-P180 HCl
- 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
- WHI-P180, HYDROCHLORIDE