肿瘤归巢肽LYP-1
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- CAS号:
- 454487-07-1
- 英文名:
- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide
- 英文别名:
- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide
- 中文名:
- 肿瘤归巢肽LYP-1
- 中文别名:
- 肿瘤归巢肽LYP-1
- CBNumber:
- CB08370927
- 分子式:
- C36H65N17O12S2
- 分子量:
- 992.14
- MOL File:
- 454487-07-1.mol
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肿瘤归巢肽LYP-1化学性质
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密度:
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1.65±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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2.95±0.70(Predicted)
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肿瘤归巢肽LYP-1性质、用途与生产工艺
LyP-1 是一种环状 9 个氨基酸的肿瘤的定位肽，在多种肿瘤相关细胞中，选择性结合其 p32 receptor 蛋白。
LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide.The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×10
6
photon/cm
2
/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide.
肿瘤归巢肽LYP-1
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454487-07-1, 肿瘤归巢肽LYP-1 相关搜索:
- 目录肽
- C36H65N17O12S2
- 肿瘤归巢肽LYP-1
- 454487-07-1
- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide