1H-吲哚-5-甲酰胺
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- CAS号:
- 1670-87-7
- 英文名:
- 1H-INDOLE-5-CARBOXAMIDE, 97%
- 英文别名:
- SD-169;5-CarbaMoylindole;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI);p38 MAP Kinase Inhibitor VII, SD-169;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
- 中文名:
- 1H-吲哚-5-甲酰胺
- 中文别名:
- 5-羧酰氨基吲哚;5-氨基甲酰吲哚;吲哚-5-甲酰胺;1H-吲哚-5-甲酰胺;5-(氨基羰基)-1H-吲哚;1H-吲哚-5-甲酰胺(SD-169)
- CBNumber:
- CB0972248
- 分子式:
- C9H8N2O
- 分子量:
- 160.17
- MOL File:
- 1670-87-7.mol
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1H-吲哚-5-甲酰胺化学性质
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熔点:
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159-163 °C
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沸点:
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457.6±18.0 °C(Predicted)
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密度:
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1.328±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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16.25±0.30(Predicted)
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形态:
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Off-white solid
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颜色:
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Off-White to Light Purple
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1H-吲哚-5-甲酰胺性质、用途与生产工艺
SD-169 是一种有口服活性的 ATP 竞争性 MAPK p38α 抑制剂,其 IC50 值为 3.2 nM。SD-169 对 p38β MAPK 也有较弱的抑制作用,其 IC50 值为 122 nM。SD-169 通过抑制 T 细胞的浸润和活化阻止糖尿病的发展。
p38α MAPK
3.2 nM (IC
50
)
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p38β MAPK
122 nM (IC
50
)
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SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets.
SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC
50
=3.2 nM) than p38β MAP kinase (IC
50
=122 nM).
1H-吲哚-5-甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-W015445 | SD-169 | | 5 mg | 140元 |
2024/04/30 | HY-W015445 | 1H-吲哚-5-甲酰胺 SD-169 | 1670-87-7 | 10mM * 1mLin DMSO | 154元 |
1670-87-7, 1H-吲哚-5-甲酰胺 相关搜索:
- Heterocyclic Compounds
- AMIDE
- 高端化学
- 1H-吲哚-5-甲酰胺(SD-169)
- 吲哚-5-甲酰胺
- 1H-吲哚-5-甲酰胺
- 5-羧酰氨基吲哚
- 5-氨基甲酰吲哚
- 5-(氨基羰基)-1H-吲哚
- 1670-87-7
- 1H-indole-5-carboxamide(SD-169)
- HSPs,p38α,kinases,SD-169,protein,inhibit,Inhibitor,p38 MAPK,MAPK,SD169,heat,diabete,mitogen-activated,proteins,shock
- Indole-5-carboxamide (7CI, 8CI)
- p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem
- 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
- p38 MAP Kinase Inhibitor VII, SD-169
- 5-CarbaMoylindole
- 5-(AMinocarbonyl)-1H-indole
- 1H-Indole-5-carboxamide(9CI)
- SD-169
- 1H-INDOLE-5-CARBOXAMIDE, 97%