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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
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- CAS号:
- 350997-39-6
- 英文名:
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- 英文别名:
- OGG1-IN-08;OGG1-IN-O8;O8 OGG1 Inhibitor;OGG1 Inhibitor O8;OGG1 Inhibitor O8 >=98% (HPLC);3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide;3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE;Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide;Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- 中文名:
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- 中文别名:
- O8 OGG1抑制剂;化合物OGG1-IN-O8;3,4-二氯苯并[B]噻吩-2-甲酰肼
- CBNumber:
- CB11499417
- 分子式:
- C9H6Cl2N2OS
- 分子量:
- 261.13
- MOL File:
- 350997-39-6.mol
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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE化学性质
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密度:
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1.587±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
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形态:
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powder
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酸度系数(pKa):
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11.75±0.30(Predicted)
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颜色:
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white to beige
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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE性质、用途与生产工艺
OGG1-IN-08 是一种有效的 8-氧鸟嘌呤 DNA 糖基酶-1 (OGG1) 抑制剂，其 IC50 值为 0.22 μM。OGG1-IN-08 降低 OGG1 的糖基化酶和裂解酶活性。
OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-112902 | OGG1-IN-08 | | 1 mg | 240元 |
| 2024/04/30 | HY-112902 | 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
OGG1-IN-08 | 350997-39-6 | 5mg | 600元 |
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
生产厂家
350997-39-6, 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 相关搜索:
- 药靶配体
- O8 OGG1抑制剂
- 化合物OGG1-IN-O8
- 3,4-二氯苯并[B]噻吩-2-甲酰肼
- 350997-39-6
- Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide
- Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- OGG1-IN-08
- OGG1 Inhibitor O8 >=98% (HPLC)
- OGG1-IN-O8
- 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
- O8 OGG1 Inhibitor
- OGG1 Inhibitor O8
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE