网站主页 >> CAS数据库列表 >> (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺
(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺
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- CAS号:
- 942183-80-4
- 英文名:
- SCH772984
- 英文别名:
- CS-1135;SCH772984;SCH772984, >=98%;SCH772984 USP/EP/BP;SCH772984/SCH-772984;SCH772984 HCl(free base);SCH772984 TFA(free base);(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indaz;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-;(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
- 中文名:
- (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺
- 中文别名:
- ERK1和ERK2活性抑制剂(SCH772984);(R)-1-(2-氧代-2-(4-(4-(2-嘧啶L)苯基)-L-哌嗪)乙基)-3-[N-;1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯;(R)-1-(2-氧代-2-(4-(4-(2-嘧啶L)苯基)-L-哌嗪)乙基)-3-[N-(3-(4-吡啶)吲唑-5-氨基]甲酰基-吡咯烷;(3R)-1-[2-氧代-2-[4-[4-(2-嘧啶基)苯基]-1-哌嗪基]乙基]-N-[3-(4-吡啶基)-1H-吲唑-5-基]-3-吡咯烷甲酰胺;(R)-1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)-N-(3-(吡啶-4-基)-1H-吲唑-5-基)吡咯烷-3-甲酰胺;(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺;(3R)-1-[2-氧代-2-[4-[4-(2-嘧啶基)苯基]-1-哌嗪基]乙基]-N-[3-(4-吡啶基)-1H-吲唑-5-基]-3-吡咯烷甲酰胺, 一种选择性ERK1/2抑制剂
- CBNumber:
- CB12473742
- 分子式:
- C33H33N9O2
- 分子量:
- 587.67
- MOL File:
- 942183-80-4.mol
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(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺化学性质
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熔点:
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>214°C (dec.)
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沸点:
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857.3±65.0 °C(Predicted)
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密度:
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1.353±0.06(20.0000℃)
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly)
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酸度系数(pKa):
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12.05±0.40(Predicted)
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形态:
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Solid
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颜色:
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Pale Yellow
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CAS 数据库:
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942183-80-4
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(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺性质、用途与生产工艺
SCH772984是一种新型特异性的ERK1/2抑制剂,无细胞试验中IC50分别为4 nM和1 nM, 对含有RAS或BRAF突变的癌细胞具有强大的功效。
Target | Value |
ERK2
(Cell-free assay)
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1 nM
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ERK1
(Cell-free assay)
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4 nM
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SCH772984是新型,选择性,ATP竞争性的ERK1/2抑制剂。SCH772984抑制ERK底物p90核糖体S6激酶(T359/S363 磷酸化-RSK)的磷酸化,这种作用存在剂量依赖性。SCH772984也能抑制ERK自身活化环中残基的磷酸化。SCH772984分别抑制约88%和49%BRAF突变型或RAS-突变型肿瘤细胞系,EC50值<500 nM。
SCH772984按耐受剂量处理移植瘤模型,诱导肿瘤衰退。SCH772984作用于抗BRAF或MEK抑制剂的模型,有效抑制MAPK信号和细胞增殖。
(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-50846 | SCH772984 | | 1 mg | 719元 |
2024/04/30 | HY-50846 | (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺 SCH772984 | 942183-80-4 | 2mg | 1050元 |
(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺
生产厂家
942183-80-4, (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺 相关搜索:
- MAPK
- api
- Inhibitors
- 合成有机化合物配体
- 生化试剂-小分子化合物
- 对照品
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- C33H33N9O2
- (R)-1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)-N-(3-(吡啶-4-基)-1H-吲唑-5-基)吡咯烷-3-甲酰胺
- (3R)-1-[2-氧代-2-[4-[4-(2-嘧啶基)苯基]-1-哌嗪基]乙基]-N-[3-(4-吡啶基)-1H-吲唑-5-基]-3-吡咯烷甲酰胺, 一种选择性ERK1/2抑制剂
- ERK1和ERK2活性抑制剂(SCH772984)
- (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺
- 1-(2-氧代-2-(4-(4-(嘧啶-2-基)苯基)哌嗪-1-基)乙基)吡咯烷-3-甲酸(R)-甲酯
- (3R)-1-[2-氧代-2-[4-[4-(2-嘧啶基)苯基]-1-哌嗪基]乙基]-N-[3-(4-吡啶基)-1H-吲唑-5-基]-3-吡咯烷甲酰胺
- (R)-1-(2-氧代-2-(4-(4-(2-嘧啶L)苯基)-L-哌嗪)乙基)-3-[N-(3-(4-吡啶)吲唑-5-氨基]甲酰基-吡咯烷
- (R)-1-(2-氧代-2-(4-(4-(2-嘧啶L)苯基)-L-哌嗪)乙基)-3-[N-
- 942183-80-4
- (R)-1-{2-Oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid (3-pyridin-4-yl-1H-indazol-5-yl)-amide
- SCH772984 TFA(free base)
- SCH772984 HCl(free base)
- SCH772984 USP/EP/BP
- 3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-, (3R)-
- CS-1135
- (3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
- (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide, 98%, a selective inhibitor of ERK1/2
- (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indaz
- SCH772984, >=98%
- (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-
- (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide SCH772984
- (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide
- (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide
- SCH772984/SCH-772984
- SCH772984