CCMI
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- CAS号:
- 917837-54-8
- 英文名:
- [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
- 英文别名:
- CCMI;AVL-3288;AVL-3288 (CCMI);N-(4-Chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide;N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide;(E)-3-(4-chloroanilino)-N-(4-chlorophenyl)-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide;[N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide;5-IsoxazoleacetaMide, N-(4-chlorophenyl)-α-[[(4-chlorophenyl)aMino]Methylene]-3-Methyl-;Inhibitor,AVL 3288,inhibit,UCI 4083,Nicotinic acetylcholine receptors,CCMI,nAChR,AVL3288,UCI4083,UCI-4083
- 中文名:
- CCMI
- 中文别名:
- 化合物CCMI;CCMI,Α7NACHRS的正变构调节剂;N-(4-氯苯基)-3-((4-氯苯基)氨基)-2-(3-甲基异恶唑-5-基)丙烯酰胺
- CBNumber:
- CB12518975
- 分子式:
- C19H15Cl2N3O2
- 分子量:
- 388.25
- MOL File:
- 917837-54-8.mol
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CCMI化学性质
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沸点:
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605.4±55.0 °C(Predicted)
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密度:
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1.412±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO (Slightly), Methanol (Very Slightly)
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形态:
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Solid
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酸度系数(pKa):
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10.37±0.70(Predicted)
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颜色:
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Off-White to Pale Yellow
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CCMI性质、用途与生产工艺
CCMI 是一种有效、选择性的 α7 nAChR 正向别构调节剂，不是通过正性结合位点与 α7 nAChR 结合并使其激活，能有效正向调节 α7 nAChR 上激动剂诱导的电流。CCMI 在神经系统认知功能紊乱疾病中具有潜在疗效。
CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs.
CCMI
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12150 | CCMI
CCMI | 917837-54-8 | 5mg | 800元 |
| 2024/04/30 | HY-12150 | CCMI
CCMI | 917837-54-8 | 10mM * 1mLin DMSO | 880元 |
917837-54-8, CCMI 相关搜索:
- 药靶配体
- CCMI,Α7NACHRS的正变构调节剂
- 化合物CCMI
- N-(4-氯苯基)-3-((4-氯苯基)氨基)-2-(3-甲基异恶唑-5-基)丙烯酰胺
- 917837-54-8
- Inhibitor,AVL 3288,inhibit,UCI 4083,Nicotinic acetylcholine receptors,CCMI,nAChR,AVL3288,UCI4083,UCI-4083
- AVL-3288 (CCMI)
- N-(4-Chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide
- N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
- AVL-3288
- (E)-3-(4-chloroanilino)-N-(4-chlorophenyl)-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide
- 5-IsoxazoleacetaMide, N-(4-chlorophenyl)-α-[[(4-chlorophenyl)aMino]Methylene]-3-Methyl-
- CCMI
- [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide