N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
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- CAS号:
- 489402-47-3
- 英文名:
- ML213
- 英文别名:
- CS-2507;CID3111211;CID 3111211;ML-213(CID-3111211);ML213;ML 213;CID 3111211;CID3111211;N-(2,4,6-TriMethylphenyl)-bicyclo[2.2.1]heptane-2-carboxaMide;Bicyclo[2.2.1]heptane-2-carboxamide, N-(2,4,6-trimethylphenyl)-
- 中文名:
- N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
- 中文别名:
- 化合物ML213;ML213,KV7.2和KV7.4通道开启器;N-均三甲基苯基双环[2.2.1]庚烷-2-甲酰胺;N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
- CBNumber:
- CB12642779
- 分子式:
- C17H23NO
- 分子量:
- 257.37
- MOL File:
- 489402-47-3.mol
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N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺化学性质
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沸点:
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398.8±11.0 °C(Predicted)
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密度:
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1.106±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble5mg/mL, clear (warmed)
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酸度系数(pKa):
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14.79±0.70(Predicted)
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形态:
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powder
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颜色:
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white to beige
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N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺性质、用途与生产工艺
ML213 (CID-3111211) 是一种选择性的 KCNQ2 (Kv7.2) 和 KCNQ4 (Kv7.4) potassium channel 的开放剂，EC50值分别为230 nM和510 nM。
EC50: 230 nM (Kv7.2 channel), 510 nM (Kv7.4 channel)
ML213 (100 nM-30 µM) increases maximal conductance to a peak at 212% ± 27% of control, with an EC
50
of 0.8 ± 0.3 µM. ML213 (10 µM) reduces the deactivation rates of Kv7.4 currents by 4.6-fold in the voltage range from −130 mV to −90 mV. ML213 is a potent and effective activator of homomeric Kv7.5 channels overexpressed in A7r5 cells. ML213 increases maximal conductance of Kv7.5 channels with an EC
50
of 0.7 ± 0.2 µM. ML213 (10 µM) also reduces deactivation rates of Kv7.5 currents by 5.9-fold on average. ML213 produces similar effects on heteromeric Kv7.4/7.5 channels: 204% ± 11% maximal increase in conductance with an EC
50
of 1.1 ± 0.6 µM and a 34.2 ± 3.3 mV maximal negative shift of the activation curve, with an EC
50
of 3.8 ± 1.2 µM. ML213 causes a vasorelaxation in different precontracted rat blood vessels. ML213 (10 μM) also hyperpolarizes mesenteric artery smooth muscle cells. ML213 causes a concentration-dependent shift in the V1/2 for KCNQ2 activation with an EC
50
340 ± 70 nM and a maximal shift of 37.4 mV.
N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | S6553 | N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
ML213 | 489402-47-3 | 5mg | 620.34元 |
| 2023/03/20 | S6553 | N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
ML213 | 489402-47-3 | 25mg | 2180.36元 |
N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
生产厂家
489402-47-3, N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺 相关搜索:
- 合成有机化合物配体
- ML213,KV7.2和KV7.4通道开启器
- 化合物ML213
- N-均三甲基苯基双环[2.2.1]庚烷-2-甲酰胺
- N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
- 489402-47-3
- Bicyclo[2.2.1]heptane-2-carboxamide, N-(2,4,6-trimethylphenyl)-
- ML-213(CID-3111211)
- CS-2507
- ML213;ML 213;CID 3111211;CID3111211
- CID3111211
- CID 3111211
- N-(2,4,6-TriMethylphenyl)-bicyclo[2.2.1]heptane-2-carboxaMide