化合物 T21557
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- CAS号:
- 1956426-56-4
- 英文名:
- KN93 hydrochloride
- 英文别名:
- CS-1449;KN-93 HCl;KN-93-HCI;KN-93 HCI;KN93 (HCI);KN-93 (HCI);KN93 hydrochloride;KN 93 hydrochloride;KN-93 (hydrochloride)
- 中文名:
- 化合物 T21557
- 中文别名:
- 化合物 T21557;钙离子/钙调蛋白依赖激酶II(CAMKII)抑制剂(KN-93 HYDROCHLORIDE)
- CBNumber:
- CB12666647
- 分子式:
- C26H30Cl2N2O4S
- 分子量:
- 537.5
- MOL File:
- 1956426-56-4.mol
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化合物 T21557化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF:10.0(Max Conc. mg/mL);18.6(Max Conc. mM)
DMSO:20.5(Max Conc. mg/mL);38.14(Max Conc. mM) Water:0.45(Max Conc. mg/mL);0.84(Max Conc. mM)-
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形态:
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A crystalline solid
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化合物 T21557性质、用途与生产工艺
KN-93 hydrochloride是可渗透细胞,可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂,Ki 为370 nM。
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H
+
, K
+
-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca
2+
-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.
化合物 T21557
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-15465A | KN-93 hydrochloride | 1956426-56-4 | 5mg | 1100元 |
2024/04/30 | HY-15465A | KN-93 hydrochloride | 1956426-56-4 | 10mM * 1mLin DMSO | 1301元 |
1956426-56-4, 化合物 T21557 相关搜索:
- 细胞生物学试剂
- C26H30Cl2N2O4S
- 化合物 T21557
- 钙离子/钙调蛋白依赖激酶II(CAMKII)抑制剂(KN-93 HYDROCHLORIDE)
- 1956426-56-4
- KN-93-HCI
- KN-93 HCI
- KN-93 (HCI)
- KN93 (HCI)
- CS-1449
- KN-93 HCl
- KN93 hydrochloride
- KN-93 (hydrochloride)
- KN 93 hydrochloride