1227301-51-0
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- CAS号:
- 1227301-51-0
- 英文名:
- Philanthotoxin 74
- 英文别名:
- PhTx 74。2HCl;PhTx-74 diHCl;PhTx-74 dihydrochloride;Philanthotoxin 74 dihydrochloride;Philanthotoxin 74 (hydrochloride);(S)-N-(1-((7-((4-Aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide dihydrochloride;Benzenepropanamide, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]-, hydrochloride (1:2), (αS)-
- 中文名:
- 1227301-51-0
- 中文别名:
- 化合物 T16524;PHILANTHOTOXIN 74二盐酸盐;化合物PHILANTHOTOXIN 74 盐酸盐
- CBNumber:
- CB13037464
- 分子式:
- C24H43ClN4O3
- 分子量:
- 471.08
- MOL File:
- 1227301-51-0.mol
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1227301-51-0化学性质
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMSO : 100 mg/mL (197.03 mM; Need ultrasonic)H2O : 50 mg/mL (98.51 mM; Need ultrasonic)
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形态:
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Powder
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1227301-51-0性质、用途与生产工艺
Philanthotoxin 74 dihydrochloride (PhTx 74) 是 AMPAR 的拮抗剂; 抑制 GluR3 和 GluR1 的 IC50 值分别为263和296 nM。
IC50: 296 nM (GluR1), 296 nM (GluR1)
Ki: 0.29 μM (GluR5Q)
Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC
50
values of about 30 μM, in both the presence and absence of γ-2.
1227301-51-0
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-104020A | 1227301-51-0
Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 1mg | 500元 |
| 2024/04/30 | HY-104020A | 1227301-51-0
Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 5mg | 800元 |
1227301-51-0, 1227301-51-0 相关搜索:
- PHILANTHOTOXIN 74二盐酸盐
- 化合物PHILANTHOTOXIN 74 盐酸盐
- 化合物 T16524
- 1227301-51-0
- (S)-N-(1-((7-((4-Aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide dihydrochloride
- PhTx-74 diHCl
- PhTx-74 dihydrochloride
- Benzenepropanamide, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]-, hydrochloride (1:2), (αS)-
- PhTx 74。2HCl
- Philanthotoxin 74 dihydrochloride
- Philanthotoxin 74 (hydrochloride)