1384268-04-5
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- CAS号:
- 1384268-04-5
- 英文名:
- SYP-5
- 英文别名:
- SYP-5;SYP5; SYP 5;SYP-5 >=98% (HPLC);(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-;SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
- 中文名:
- 1384268-04-5
- 中文别名:
- 化合物SYP-5;HIF-1抑制剂(SYP-5);(E)-1-(5-羟基-2,2-二甲基-2H-苯并吡喃-6-基)-3-(噻吩-2-基)丙-2-烯-1-酮
- CBNumber:
- CB13145907
- 分子式:
- C18H16O3S
- 分子量:
- 312.38
- MOL File:
- 1384268-04-5.mol
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1384268-04-5化学性质
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沸点:
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502.0±50.0 °C(Predicted)
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密度:
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1.263±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM)-
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形态:
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A solid
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酸度系数(pKa):
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7.12±0.40(Predicted)
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1384268-04-5性质、用途与生产工艺
SYP-5 是一种 Hypoxia-inducible factor-1 (HIF-1) 的抑制剂，可抑制肿瘤细胞迁移和侵袭以及肿瘤血管生成。
SYP-5 inhibits hypoxia-induced upregulation of HIF-1. SYP-5 inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down-regulated by SYP-5. SYP-5 displays significant inhibition on hypoxia-induced overexpression of VEGF and MMP2 in both cell lines. In the tube formation assay, SYP-5 suppresses angiogenesis induced by hypoxia and VEGF in vitro. SYP-5 also retards the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. SYP-5 specifically inhibits hypoxic induction of luciferase expression in U251-HRE but not in U251-pGL3.
1384268-04-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100693 | 1384268-04-5
SYP-5 | 1384268-04-5 | 5mg | 910元 |
| 2024/04/30 | HY-100693 | 1384268-04-5
SYP-5 | 1384268-04-5 | 10mM * 1mLin DMSO | 1001元 |
1384268-04-5, 1384268-04-5 相关搜索:
- 药靶配体
- 细胞生物学试剂
- (E)-1-(5-羟基-2,2-二甲基-2H-苯并吡喃-6-基)-3-(噻吩-2-基)丙-2-烯-1-酮
- 化合物SYP-5
- HIF-1抑制剂(SYP-5)
- 1384268-04-5
- (E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one
- SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
- SYP-5 >=98% (HPLC)
- 2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-
- SYP5; SYP 5
- SYP-5