巯基-四聚乙二醇-丙炔基
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- CAS号:
- 1347750-80-4
- 英文名:
- Propargyl-PEG4-thiol
- 英文别名:
- SH-PEG4-ALKYNE;HC≡C-CH2-PEG4-SH;CAS_1347750-80-4;ALKYNE-PEG4-THIOL;Propyne-PEG4-thiol;Propargyl-PEG4-thiol;3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
- 中文名:
- 巯基-四聚乙二醇-丙炔基
- 中文别名:
- 炔-PEG4-巯基;炔基四聚乙二醇巯基;巯基-聚乙二醇-炔基;炔-四聚乙二醇-巯基;丙炔-四聚乙二醇-巯基;巯基-四聚乙二醇-丙炔基
- CBNumber:
- CB13155016
- 分子式:
- C11H20O4S
- 分子量:
- 248.3391
- MOL File:
- 1347750-80-4.mol
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巯基-四聚乙二醇-丙炔基化学性质
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沸点:
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332.9±37.0 °C(Predicted)
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密度:
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1.064±0.06 g/cm3(Predicted)
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溶解度:
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Soluble in DMSO, DCM, DMF
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酸度系数(pKa):
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9?+-.0.10(Predicted)
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巯基-四聚乙二醇-丙炔基性质、用途与生产工艺
Propargyl-PEG4-thiol 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG4-thiol 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-thiol 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
巯基-四聚乙二醇-丙炔基
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1347750-80-4, 巯基-四聚乙二醇-丙炔基 相关搜索:
- peg
- 巯基-聚乙二醇-炔基
- 炔基四聚乙二醇巯基
- 炔-四聚乙二醇-巯基
- 丙炔-四聚乙二醇-巯基
- 炔-PEG4-巯基
- 巯基-四聚乙二醇-丙炔基
- 1347750-80-4
- CAS_1347750-80-4
- 3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
- ALKYNE-PEG4-THIOL
- SH-PEG4-ALKYNE
- Propyne-PEG4-thiol
- HC≡C-CH2-PEG4-SH
- Propargyl-PEG4-thiol