1599432-18-4
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- CAS号:
- 1599432-18-4
- 英文名:
- Ibrutinib-biotin
- 英文别名:
- Ibrutinib-biotin;Ibrutinib-biotin-1;Reaxys ID: 26833452;N1-(4-(((E)-4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)(methyl)amino)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide;Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-
- 中文名:
- 1599432-18-4
- 中文别名:
- 依鲁替尼生物素;BTK抑制剂(IBRUTINIB-BIOTIN);N1-(4-((4-(R)-3-(4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶-1-基)哌啶) -1-基)-4-氧代丁-2-烯-1-基)(甲基)氨基)丁基)-N5-(15-氧代-19-((3AS,4S,6AR)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)-4,7,10-三氧杂-14-氮杂十九烷基)戊二酰胺
- CBNumber:
- CB13155061
- 分子式:
- C56H80N12O9S
- 分子量:
- 1097.3744
- MOL File:
- 1599432-18-4.mol
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1599432-18-4化学性质
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沸点:
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1288.9±65.0 °C(Predicted)
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 50 mg/mL (45.56 mM)
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酸度系数(pKa):
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13.90±0.40(Predicted)
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1599432-18-4性质、用途与生产工艺
Ibrutinib-biotin 是一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针,具体可参考 WO2014059368A1 中 Compound 1-5,抑制 BTK,IC50 值为 0.755-1.02 nM。
IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)
Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells.
1599432-18-4
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-100342 | Ibrutinib-biotin | | 1 mg | 2400元 |
2024/04/30 | HY-100342 | 1599432-18-4 Ibrutinib-biotin | 1599432-18-4 | 5mg | 6000元 |
1599432-18-4, 1599432-18-4 相关搜索:
- 细胞生物学试剂
- C56H80N12O9S
- N1-(4-((4-(R)-3-(4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶-1-基)哌啶) -1-基)-4-氧代丁-2-烯-1-基)(甲基)氨基)丁基)-N5-(15-氧代-19-((3AS,4S,6AR)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)-4,7,10-三氧杂-14-氮杂十九烷基)戊二酰胺
- BTK抑制剂(IBRUTINIB-BIOTIN)
- 依鲁替尼生物素
- 1599432-18-4
- N1-(4-(((E)-4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)(methyl)amino)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide
- Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-
- Reaxys ID: 26833452
- Ibrutinib-biotin-1
- Ibrutinib-biotin