DBCO-PEG4-amine
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- CAS号:
- 1840886-10-3
- 英文名:
- DBCO-PEG4-amine
- 英文别名:
- DBCO-PEG2-amine TFA salt;DBCO-PEG4-amine TFA salt;Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-;N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
- 中文名:
- DBCO-PEG4-amine
- 中文别名:
- 二苯并环辛炔-四聚乙二醇-胺;二苯基环辛炔-四聚乙二醇-胺;二苯并环辛炔-四聚乙二醇-氨基
- CBNumber:
- CB14849428
- 分子式:
- C29H37N3O6
- 分子量:
- 523.63
- MOL File:
- 1840886-10-3.mol
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DBCO-PEG4-amine化学性质
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沸点:
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784.1±60.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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溶解度:
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Soluble in DMSO, DCM, DMF
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酸度系数(pKa):
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15.14±0.46(Predicted)
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InChIKey:
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NFJQULPXXATMFO-UHFFFAOYSA-N
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SMILES:
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C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN
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DBCO-PEG4-amine性质、用途与生产工艺
DBCO-PEG4-amine 是一种 PROTAC 连接桥，属于 PEG 类。DBCO-PEG4-amine 可用于合成一系列 PROTAC 分子。DBCO-PEG4-amine 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。DBCO-PEG4-amine 可用来合成一种同双功能叠氮化物至叠氮化物交联剂 FPM-PEG4-DBCO。
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
DBCO-PEG4-amine
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1840886-10-3, DBCO-PEG4-amine 相关搜索:
- 二苯并环辛炔-四聚乙二醇-氨基
- 二苯并环辛炔-四聚乙二醇-胺
- 二苯基环辛炔-四聚乙二醇-胺
- 1840886-10-3
- N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
- Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-
- DBCO-PEG2-amine TFA salt
- DBCO-PEG4-amine TFA salt