Trastuzumab Deruxtecan
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- CAS号:
- 1826843-81-5
- 英文名:
- Trastuzumab Deruxtecan
- 英文别名:
- Trastuzumab Deruxtecan;Fam-trastuzumab deruxtecan;Trastuzumab deruxtecan (solution)
- 中文名:
- Trastuzumab Deruxtecan
- 中文别名:
- 曲妥珠单抗-德鲁替康;德卢替康-曲妥珠单抗
- CBNumber:
- CB18081028
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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Trastuzumab Deruxtecan化学性质
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储存条件:
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Solution, -20°C, 2 years
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溶解度:
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Soluble in acetonitrile
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Trastuzumab Deruxtecan性质、用途与生产工艺
Trastuzumab deruxtecan (DS-8201a) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-药物偶联物 (ADC)。 Trastuzumab deruxtecan 由人源化抗 HER2 抗体，酶促裂解的肽接头和拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan 可用于 HER2 阳性乳腺癌和胃癌的研究。
Trastuzumab deruxtecan (1 pM-10 nM; 5 days) inhibits the growth of HER2‐positive KPL‐4 cells, with an IC
50
of 109.7 pM.
Trastuzumab deruxtecan (10 nM; 5 days) shows bystander killing effects in HER2‐negative MDA‐MB‐468 cells.
Cell Viability Assay
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Cell Line:
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KPL‐4 and MDA‐MB‐468 cells
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Concentration:
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1, 10, 100, 1000, 10000 pM
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Incubation Time:
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5 days
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Result:
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Killed both HER2‐positive KPL‐4 cells and HER2‐negative MDA‐MB‐468 cells.
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Trastuzumab deruxtecan (3 mg/kg; a single i.v.) shows antitumor activity against not only HER2‐positive tumors but also HER2‐negative tumors under the co‐inoculated condition.
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model.
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Animal Model:
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Female BALB/c nude mice injected with NCI‐N87 and MDA‐MB‐468‐Luc cells
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Dosage:
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3 mg/kg
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Administration:
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A single i.v.
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Result:
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Almost all of the HER2‐positive and HER‐negative cells disappeared and there were little or no cancer cells remaining in the tumors.
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Trastuzumab Deruxtecan
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-138298 | Trastuzumab Deruxtecan
Trastuzumab deruxtecan | 1826843-81-5 | 1mg(10mg/mL * 100μL in Aqueous solution) | 6400元 |
| 2024/04/30 | HY-138298A | Trastuzumab Deruxtecan
Trastuzumab deruxtecan | 1826843-81-5 | 1 mg | 6400元 |
Trastuzumab Deruxtecan
生产厂家
1826843-81-5, Trastuzumab Deruxtecan 相关搜索:
- 化学试剂
- 医药原料
- 曲妥珠单抗-德鲁替康
- 德卢替康-曲妥珠单抗
- 1826843-81-5
- Fam-trastuzumab deruxtecan
- Trastuzumab deruxtecan (solution)
- Trastuzumab Deruxtecan