RHO-激酶抑制剂
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- CAS号:
- 155558-32-0
- 英文名:
- HYDROXYFASUDIL MONOHYDROCHLORIDE
- 英文别名:
- Fasudil Hydroxy;Hydroxyfasudil HCl;Fasudil Impurity 7 HCl;Hydroxyfasudil (HA-1100);Hydroxyfasudil HCl (HA1100);Hydroxyfasudil Hydrochloride;Hydroxyfasudil (HA-1100) HCl;HYDROXYFASUDIL MONOHYDROCHLORIDE;Hydroxyfasudil hydrochloride hydrate;HA 1100 hydrochloride (Hydroxyfasudil)
- 中文名:
- RHO-激酶抑制剂
- 中文别名:
- 羟基法舒地尔;1-羟基法舒地尔;羟基法舒地尔盐酸盐;RHO-激酶抑制剂;羟基法舒地尔单盐酸盐;法舒地尔杂质7(HCL);HA 1100盐酸盐(羟基法舒地尔盐酸盐);1-(1-羟基-5-异喹啉磺酰基)高哌嗪盐酸盐;5-[(1,4-二氮杂环庚烷-1-基)磺酰基]异喹啉-1(2H)-酮盐酸盐
- CBNumber:
- CB1973040
- 分子式:
- C14H18ClN3O3S
- 分子量:
- 343.82902
- MOL File:
- 155558-32-0.mol
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RHO-激酶抑制剂化学性质
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熔点:
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>250 (dec.)
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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H2O: >5mg/mL
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形态:
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solid
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颜色:
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white
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水溶解性:
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Soluble in water (20mM)
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InChIKey:
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XWWFOUVDVJGNNG-UHFFFAOYSA-N
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RHO-激酶抑制剂性质、用途与生产工艺
Hydroxyfasudil hydrochloride 是一种 ROCK 抑制剂,可抑制 ROCK1 和 ROCK2 的活性,IC50 值分别为 0.73 和 0.72 μM。
ROCK2
0.72 μM (IC
50
)
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ROCK1
0.73 μM (IC
50
)
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PKA
37 μM (IC
50
)
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Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC
50
s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC
50
of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC
50
value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM.
Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats.
RHO-激酶抑制剂
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-13911A | Hydroxyfasudil hydrochloride | | 1 mg | 280元 |
2024/04/30 | HY-13911A | RHO-激酶抑制剂 Hydroxyfasudil hydrochloride | 155558-32-0 | 5mg | 700元 |
RHO-激酶抑制剂
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RHO-激酶抑制剂国内生产厂家
155558-32-0, RHO-激酶抑制剂 相关搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Various Metabolites and Impurities
- 药靶配体
- 杂质
- C14H17N3O3SHCl
- HA 1100盐酸盐(羟基法舒地尔盐酸盐)
- 法舒地尔杂质7(HCL)
- 5-[(1,4-二氮杂环庚烷-1-基)磺酰基]异喹啉-1(2H)-酮盐酸盐
- 羟基法舒地尔单盐酸盐
- 1-羟基法舒地尔
- 1-(1-羟基-5-异喹啉磺酰基)高哌嗪盐酸盐
- RHO-激酶抑制剂
- 羟基法舒地尔
- 羟基法舒地尔盐酸盐
- 155558-32-0
- HA 1100 hydrochloride (Hydroxyfasudil)
- Hydroxyfasudil hydrochloride hydrate Hydroxyfasudil hydrochloride
- HA-1100,ROCK,Hydroxyfasudil Hydrochloride,Hydroxyfasudil,Rho-associated kinase,HA 1100,inhibit,HA1100,Rho-kinase,Rho-associated protein kinase,ROK,Inhibitor
- 5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one,hydrochloride
- Hydroxyfasudil HCl (HA1100)
- 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
- 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride
- Fasudil Hydroxy
- Fasudil Impurity 7 HCl
- 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
- Hydroxyfasudil (HA-1100) HCl
- Hydroxyfasudil HCl
- Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
- Hydroxyfasudil hydrochloride (HA-1100 hydrochloride)
- 5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one
- HA-1100 HYDROCHLORIDE;HA 1100 HYDROCHLORIDE;HA1100 HYDROCHLORIDE
- Hydroxyfasudil (HA-1100)
- Hydroxyfasudil hydrochloride hydrate
- 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
- Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
- HYDROXYFASUDIL MONOHYDROCHLORIDE
- 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride
- Hydroxyfasudil Hydrochloride
- 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone