947669-91-2
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- CAS号:
- 947669-91-2
- 英文名:
- WWL70
- 英文别名:
- WWL70;WWL 70; WWL70; WWL-70.;Inhibitor,MAGL,Monoacylglycerol lipase,WWL70,WWL 70,inhibit,WWL-70;4-CARBAMOYL-[1,1-BIPHENYL]-4-YL METHYL(3-(PYRIDIN-4-YL)BENZYL)CARBAMATE;[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate;N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-ylcarbamicacidester;Carbamic acid, N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-, 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
- 中文名:
- 947669-91-2
- 中文别名:
- 化合物WWL70;WWL70 化学试剂;WWL 70,ABHD6抑制剂;4'-氨基甲酰基-[1,1'-联苯]-4-基 甲基(3-(吡啶-4-基)苄基)氨基甲酸酯
- CBNumber:
- CB22454225
- 分子式:
- C27H23N3O3
- 分子量:
- 437.49
- MOL File:
- 947669-91-2.mol
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947669-91-2化学性质
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储存条件:
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Store at +4°C
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溶解度:
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DMSO : 17.33 mg/mL (39.61 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
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形态:
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Powder
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947669-91-2性质、用途与生产工艺
WWL70 是一个选择性的 α/β 水解酶结构域 6 (ABHD6) 抑制剂，其 IC50 值为 70 nM。
At 1 h after WWL70 (10 μM) treatment, 2-Arachidonoylglycerol (2-AG) is increased by 20% compare to untreated cells. At either 1 or 10 μM, WWL70 completely blocks the lipopolysaccharide (LPS)-induced increase of PGE
2
. The enhanced mRNA expression of mPGES-1 and mPGES-2 by LPS is also reduced by WWL70. The IC
50
of WWL70 to inhibit the PGE
2
biosynthesis is about 100 nM.
Although post-treatment with WWL70 at 5 mg/kg does not have any effect, treatment with WWL70 at 10 mg/kg improves the performance significantly. WWL70 treatment improves motor coordination of traumatic brain injury (TBI) mice in a concentration dependent manner. The latency to fall in animals treated with WWL70 at 5 mg/kg increases from 74.92±4.8 to 99.57±5.21 on day 3 (p<0.01) and from 87.32±4.42 to 100.14±3.56 on day 7 (p<0.05) post-injury when compare with the vehicle-TBI groups. At 10 mg/kg, WWL70 treatment improves motor coordination starting on day 1 post-injury. WWL70 treatment completely restores the ability of TBI mice to continuously alternate arms during Y maze exploration (69.67±4.98 %).
947669-91-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100337 | WWL70 | | 1 mg | 450元 |
| 2024/04/30 | HY-100337 | 947669-91-2
WWL70 | 947669-91-2 | 5mg | 990元 |
947669-91-2, 947669-91-2 相关搜索:
- 合成有机化合物配体
- 标准品
- WWL70 化学试剂
- WWL 70,ABHD6抑制剂
- 4'-氨基甲酰基-[1,1'-联苯]-4-基 甲基(3-(吡啶-4-基)苄基)氨基甲酸酯
- 化合物WWL70
- 947669-91-2
- Inhibitor,MAGL,Monoacylglycerol lipase,WWL70,WWL 70,inhibit,WWL-70
- Carbamic acid, N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-, 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
- [4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
- WWL 70; WWL70; WWL-70.
- 4-CARBAMOYL-[1,1-BIPHENYL]-4-YL METHYL(3-(PYRIDIN-4-YL)BENZYL)CARBAMATE
- N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-ylcarbamicacidester
- WWL70