网站主页 >> CAS数据库列表 >> 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
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- CAS号:
- 215030-90-3
- 英文名:
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
- 英文别名:
- BMS 493;BMS204, 493;BMS493,BMS-493;(E)-4-(2-(5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid;4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid;4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid;(E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid;Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-
- 中文名:
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
- 中文别名:
- 化合物 T14689;4-[(1E)-2-[5,6-二氢-5,5-二甲基-8-(2-苯基乙炔基)-2-萘基]乙烯基]苯甲酸
- CBNumber:
- CB22518846
- 分子式:
- C29H24O2
- 分子量:
- 404.5
- MOL File:
- 215030-90-3.mol
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4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid化学性质
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沸点:
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605.4±55.0 °C(Predicted)
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密度:
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1.21±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥20mg/mL
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酸度系数(pKa):
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4.27±0.10(Predicted)
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形态:
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powder
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颜色:
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light yellow to yellow
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4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid性质、用途与生产工艺
BMS493 是一种反向泛视黄酸受体 (RARs) 激动剂。BMS493 增加了 RARs 与核共抑制因子的相互作用，还可阻止视黄酸诱导的分化。
BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation.
Cell Viability Assay
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Cell Line:
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ALDHhi UCB cells
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Concentration:
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100 nM
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Incubation Time:
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6 days
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Result:
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Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls.
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Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion.
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-108529 | BMS493 | | 1 mg | 363元 |
| 2024/04/30 | HY-108529 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
BMS493 | 215030-90-3 | 5mg | 800元 |
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
生产厂家
215030-90-3, 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 相关搜索:
- 4-[(1E)-2-[5,6-二氢-5,5-二甲基-8-(2-苯基乙炔基)-2-萘基]乙烯基]苯甲酸
- 化合物 T14689
- 215030-90-3
- BMS493,BMS-493
- (E)-4-(2-(5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid
- Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-
- BMS204, 493
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid
- (E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid
- BMS 493
- 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid