1346133-11-6
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- CAS号:
- 1346133-11-6
- 英文名:
- (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
- 英文别名:
- FP3FBZ;LY2444296;(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide;Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-
- 中文名:
- 1346133-11-6
- 中文别名:
- 化合物 T11909;化合物LY2444296;(S)-3-氟-4-(4-((2-(3-氟苯基)吡咯烷-1-基)甲基)苯氧基)苯甲酰胺
- CBNumber:
- CB24858724
- 分子式:
- C24H22F2N2O2
- 分子量:
- 408.44
- MOL File:
- 1346133-11-6.mol
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1346133-11-6化学性质
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沸点:
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491.6±45.0 °C(Predicted)
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密度:
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1.276±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Ethanol: 27.5 mg/mL (67.33 mM); Methanol: 5 mg/mL (12.24 mM)
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酸度系数(pKa):
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15.61±0.50(Predicted)
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1346133-11-6性质、用途与生产工艺
LY2444296 是一种有口服生物活性、高亲和力、选择性的短效的 KOPR 拮抗剂,其 Ki 值为 ~1 nM。LY2444296 具有抗焦虑样的作用。
LY2444296 displays anti-anxiety like effects in the EPM test.
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-naïve rats.
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-naïve rats.
Animal Model:
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Adult male Sprague Dawley rats (240–250 g)
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Dosage:
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3 mg/kg
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Administration:
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Injected intraperitoneally; 30 min before U69,593 administration
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Result:
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Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-naïve rats.
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1346133-11-6
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-135230 | LY2444296 | | 1 mg | 270元 |
2024/04/30 | HY-135230 | 1346133-11-6 LY2444296 | 1346133-11-6 | 10mM * 1mLin DMSO | 770元 |
1346133-11-6, 1346133-11-6 相关搜索:
- 化合物LY2444296
- (S)-3-氟-4-(4-((2-(3-氟苯基)吡咯烷-1-基)甲基)苯氧基)苯甲酰胺
- 化合物 T11909
- 1346133-11-6
- Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-
- FP3FBZ
- LY2444296
- (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide