达巴万星盐酸盐
|
|
|
- CAS号:
- 2227366-51-8
- 英文名:
- Dalbavancin hydrochloride
- 英文别名:
- BI-397 hydrochloride;MDL-63397 hydrochloride
- 中文名:
- 达巴万星盐酸盐
- 中文别名:
- 盐酸道古霉素;盐酸达巴万星;达巴万星盐酸盐
- CBNumber:
- CB28029346
- 分子式:
- C88H101Cl3N10O28
- 分子量:
- 1853.17
- MOL File:
- 2227366-51-8.mol
|
|
|
达巴万星盐酸盐化学性质
-
储存条件:
-
under inert gas (nitrogen or Argon) at 2-8°C
-
|
-
溶解度:
-
DMSO: ≥ 24 mg/mL (12.95 mM)
-
|
-
水溶解性:
-
Water: 50 mg/mL (26.98 mM)
-
|
达巴万星盐酸盐性质、用途与生产工艺
Dalbavancin hydrochloride(MDL-63397 hydrochloride) 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌具有有效的杀菌活性。Dalbavancin hydrochloride 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90 分别为 0.06 μg/mL 和 0.25 μg/mL。
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including
S. aureus
(MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and
β-hemolytic streptococci
, organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
|
Animal Model:
|
Female BALB/c mice (6-8 weeks) challenged with Ames strain of
B. anthracis
|
|
Dosage:
|
15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
|
|
Administration:
|
Intraperitoneal injection; every 36 h or 72 h; for 14 days
|
|
Result:
|
The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
|
达巴万星盐酸盐
上下游产品信息
上游原料
下游产品
2227366-51-8, 达巴万星盐酸盐 相关搜索:
- 生化试剂
- 化工中间体
- 现货
- 化学试剂
- 精细化工原料
- 原料药
- 医药原料
- 盐酸达巴万星
- 达巴万星盐酸盐
- 盐酸道古霉素
- 2227366-51-8
- MDL-63397 hydrochloride
- BI-397 hydrochloride