网站主页 >> CAS数据库列表 >> 3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
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- CAS号:
- 138516-31-1
- 英文名:
- Bisindolylmaleimide VIII acetate salt
- 英文别名:
- Bis VIII acetate;RO 31-7549 ACETATE;BISINDOLYLMALEIMIDE VIII ACETATE SALT;BisindolylMaleiMide VIII . AcOH [Ro 31-7549];3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1);protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC
- 中文名:
- 3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
- 中文别名:
- BISINDOLYLMALEIMIDE VIII醋酸盐;化合物BISINDOLYLMALEIMIDE VIII ACETATE;RO 31-7549 ACETATE; BIS VIII ACETATE;3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
- CBNumber:
- CB32130296
- 分子式:
- C24H22N4O2
- 分子量:
- 398.464
- MOL File:
- 138516-31-1.mol
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3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐化学性质
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO
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形态:
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Red powder.
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3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐性质、用途与生产工艺
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) 是一种有效的选择性蛋白激酶 C (PKC) 抑制剂，对大鼠脑 PKC 的 IC50 为 158 nM。Bisindolylmaleimide VIII acetate 对 PKC-α，PKC-βI，PKC-βII，PKC-γ，PKC-ε 的 IC50 分别为 53、195、163、213 和 175 nM。Bisindolylmaleimide VIII acetate 促进 Fas 介导的细胞凋亡 (apoptosis)，并抑制 T 细胞介导的自身免疫性疾病。
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Rat Brain PKC
158 nM (IC
50
)
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PKC-α
53 nM (IC
50
)
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PKC-βI
195 nM (IC
50
)
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PKC-βII
163 nM (IC
50
)
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PKC-γ
213 nM (IC
50
)
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PKC-ε
175 nM (IC
50
)
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Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate; 5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners.
Bisindolylmaleimide VIII acetate (5 μM; 6 hours) significantly decreases procaspase-8 at 4 h and completely disappeares at 6 h after the combined treatment with TRA-8.
Apoptosis Analysis
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Cell Line:
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1321N1 cells
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Concentration:
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5 μM
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Incubation Time:
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8, 12 hours
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Result:
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Dramatically increased TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners.
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Western Blot Analysis
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Cell Line:
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1321N1 cells
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Concentration:
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5 μM
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Incubation Time:
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6 hours
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Result:
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Significantly decreased procaspase-8 at 4 h and completely disappeared at 6 h.
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Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate; 100 μg; IP; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. The treatment with Bisindolylmaleimide VIII acetate alone does not induce significant tumor regression.
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Animal Model:
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6-8-week-old female NOD/SCID mice.
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Dosage:
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100 μg
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Administration:
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IP; every other day for three doses
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Result:
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Resulted in nearly complete tumor regression combined toTRA-8.
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3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
上下游产品信息
上游原料
下游产品
3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
生产厂家
138516-31-1, 3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐 相关搜索:
- inhibitor
- 药靶配体
- 对照品
- RO 31-7549 ACETATE; BIS VIII ACETATE
- 化合物BISINDOLYLMALEIMIDE VIII ACETATE
- BISINDOLYLMALEIMIDE VIII醋酸盐
- 3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐
- 138516-31-1
- protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC
- 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1)
- Bis VIII acetate
- 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate
- RO 31-7549 ACETATE
- BISINDOLYLMALEIMIDE VIII ACETATE SALT
- BisindolylMaleiMide VIII . AcOH [Ro 31-7549]