网站主页 >> CAS数据库列表 >> N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE
N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE
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- CAS号:
- 436133-68-5
- 英文名:
- Kobe-0065
- 英文别名:
- CS-1281;Kobe0065;Kobe 0065;Kobe-0065;Kobe 0065, >=98%;Kobe0065/Kobe-0065;Kobe0065, 436133-68-5;N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide;Hydrazinecarbothioamide, N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-;Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
- 中文名:
- N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE
- 中文别名:
- KOBE0065,H-RAS-C-RAF1小分子抑制剂;N-(3-氯-4-甲基苯基)-2-[2,6-二硝基-4-(三氟甲基)苯基]肼基硫代甲酰胺
- CBNumber:
- CB32668155
- 分子式:
- C15H11ClF3N5O4S
- 分子量:
- 449.79
- MOL File:
- 436133-68-5.mol
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N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE化学性质
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熔点:
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>166°C (dec.)
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沸点:
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485.1±55.0 °C(Predicted)
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密度:
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1.653±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble15mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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9.25±0.70(Predicted)
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颜色:
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white to beige
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N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE性质、用途与生产工艺
Kobe0065是H-Ras-cRaf1相互作用的抑制剂,能有效抑制H-Ras·GTP与c-Raf-1 RBD的结合,Ki值为46±13 μM。
Target | Value |
H-Ras-cRaf1 interaction
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Kobe0065家族的化合物与Ras⋅GTP结合,对携带有激活ras癌基因的癌细胞具有抗增殖活性。它有效抑制了Ras⋅GTP与其效应蛋白如Raf, PI3K, RalGDS 以及调节/效应因子Sos的相互作用,对各种Ras家族的小GTP酶具有广泛的结合特异性。
Kobe0065具有抗肿瘤活性。使用该化合物处理过的肿瘤会显著增加其凋亡细胞,而没有明显的体重减少。
N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-15716 | Kobe0065 | | 5 mg | 412元 |
2024/04/30 | HY-15716 | N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE Kobe0065 | 436133-68-5 | 10mg | 660元 |
N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE
生产厂家
436133-68-5, N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE 相关搜索:
- Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
- Inhibitors
- 药靶配体
- 合成材料中间体
- 抑制剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- C15H11ClF3N5O4S
- KOBE0065,H-RAS-C-RAF1小分子抑制剂
- N-(3-氯-4-甲基苯基)-2-[2,6-二硝基-4-(三氟甲基)苯基]肼基硫代甲酰胺
- 436133-68-5
- Hydrazinecarbothioamide, N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-
- CS-1281
- Kobe0065/Kobe-0065
- Kobe 0065, >=98%
- N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide KOBE0065
- Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
- Kobe0065, 436133-68-5
- N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide
- Kobe-0065
- Kobe0065
- Kobe 0065