(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
|
|
|
- CAS号:
- 57046-73-8
- 英文名:
- Paprotrain
- 英文别名:
- Paprotrain;Kinesin,Paprotrain,Inhibitor,inhibit;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
- 中文名:
- (ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
- 中文别名:
- 化合物PAPROTRAIN;(Z)-2-(1H-吲哚-3-基)-3-(吡啶-3-基)丙烯腈;(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
- CBNumber:
- CB32677878
- 分子式:
- C16H11N3
- 分子量:
- 245.28
- MOL File:
- 57046-73-8.mol
|
|
|
(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈化学性质
-
熔点:
-
202℃
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
-
|
-
形态:
-
Powder
-
|
(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈性质、用途与生产工艺
Paprotrain是可渗透细胞的kinesin MKLP-2 的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC50 值为 1.35 μM，Ki 值为 3.36 μM，同时对 DYRK1A 有中等的抑制作用，IC50值为 5.5 μM。
Paprotrain has been screened on a panel of CNS kinases. While inactive (IC
50
>10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC
50
=5.5 μM). Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.
(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101298 | (ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
Paprotrain | 57046-73-8 | 5mg | 500元 |
| 2024/04/30 | HY-101298 | (ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
Paprotrain | 57046-73-8 | 10mg | 700元 |
(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
生产厂家
57046-73-8, (ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈 相关搜索:
- 药靶配体
- 化合物PAPROTRAIN
- (Z)-2-(1H-吲哚-3-基)-3-(吡啶-3-基)丙烯腈
- (ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
- 57046-73-8
- (Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile
- Kinesin,Paprotrain,Inhibitor,inhibit
- 1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-
- (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
- 2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile
- (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
- Paprotrain