ZT-1A
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- CAS号:
- 212135-62-1
- 英文名:
- Benzamide, 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-
- 英文别名:
- ZT-1a;Benzamide, 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-
- 中文名:
- ZT-1A
- 中文别名:
- 化合物ZT-1A
- CBNumber:
- CB38092572
- 分子式:
- C22H15Cl3N2O2
- 分子量:
- 445.73
- MOL File:
- 212135-62-1.mol
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ZT-1A化学性质
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沸点:
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538.7±50.0 °C(Predicted)
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密度:
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1.442±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 125 mg/mL (280.44 mM)
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酸度系数(pKa):
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7?+-.0.43(Predicted)
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ZT-1A性质、用途与生产工艺
ZT-1a 是一种有效的非 ATP 竞争性的选择性 SPAK 抑制剂。ZT-1a 抑制 SPAK 活性，在 ATP 浓度为 0.01、0.1 和 1 mM 时，IC50 分别为 44.3、35.0、46.7 μM。
ZT-1a inhibits Na-K-2Cl cotransporter (NKCC1) and stimulates K-Cl cotransporters (KCCs) by decreasing their SPS1-related proline/alanine-rich kinase (SPAK)-dependent phosphorylation.
ZT-1a inhibits phosphorylation of NKCC1 p-Thr203/207/212 by 72±5.2% at 1 µM ZT-1a and phosphorylation of KCC sites 1/2 by 65-77% at 3 µM in HEK-293 cells.
SPAK phosphorylation at Ser373 is inhibited by 70±3.8% inhibition at 3-10 µM ZT-1a.
ZT-1a (10 µM) inhibits NKCC1 but stimulates KCC3 activity.
ZT-1a (10-100 mg/kg) inhibits SPAK-dependent cation-Cl− cotransporters (CCC) phosphorylation in vivo.
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Animal Model:
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Naive mice
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Dosage:
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10, 30, 50, and 100 mg/kg
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Administration:
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Intraperitoneal (i.p.) administration
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Result:
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Inhibited SPAK-dependent cation-Cl
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cotransporters (CCC) phosphorylation in vivo.
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ZT-1A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136532 | ZT-1a | | 1 mg | 1591元 |
| 2024/04/30 | HY-136532 | ZT-1a | 212135-62-1 | 5mg | 3500元 |
212135-62-1, ZT-1A 相关搜索:
- 化合物ZT-1A
- 212135-62-1
- ZT-1a
- Benzamide, 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-