伊普柳氮
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- CAS号:
- 82101-17-5
- 英文名:
- ipsalazide
- 英文别名:
- 5-(Carboxymethylcarbamoyl-4-phenylazo)salicylic acid (disodium);5-[[4-[(Sodiooxycarbonylmethyl)carbamoyl]phenyl]azo]-2-hydroxybenzoic acid sodium salt;Benzoic acid, 5-((4-(((carboxymethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, disodium salt
- 中文名:
- 伊普柳氮
- 中文别名:
- 化合物 T19379
- CBNumber:
- CB41366873
- 分子式:
- 分子量:
- 0
- MOL File:
- 82101-17-5.mol
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伊普柳氮化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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伊普柳氮性质、用途与生产工艺
Ipsalazide 是一种新的柳氮磺吡啶类似物，旨在释放胃肠道中的 5-氨基水杨酸和无毒载体分子。
Sulfasalazine exerts beneficial effects in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects. Ipsalazide is designed which the sulfapyridine of sulfasalazine has been replaced by carrier molecules.
No deaths or visible abnormalities occurrs within 7 days of a single oral dose of ipsalazide (4 g/kg in mice or 2 g/kg in rats). No abnormalities were seen at postmortem. The ipsalazide carrier molecule (ABG) is readily absorbed, with nearly half of the dose appearing in the urine. However, around 40% of the ABG was not recovered, and it is possible that this has undergone further metabolism, with loss of the aromatic amine function which is the basis for the colorimetric measurement of ABG.
伊普柳氮
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82101-17-5, 伊普柳氮 相关搜索:
- 化合物 T19379
- 82101-17-5
- Benzoic acid, 5-((4-(((carboxymethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, disodium salt
- 5-(Carboxymethylcarbamoyl-4-phenylazo)salicylic acid (disodium)
- 5-[[4-[(Sodiooxycarbonylmethyl)carbamoyl]phenyl]azo]-2-hydroxybenzoic acid sodium salt