4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
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- CAS号:
- 55224-94-7
- 英文名:
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- 英文别名:
- AP-18;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal
- 中文名:
- 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
- 中文别名:
- 化合物AP 18;4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
- CBNumber:
- CB42096355
- 分子式:
- C11H12ClNO
- 分子量:
- 209.67
- MOL File:
- 55224-94-7.mol
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4-(4-氯苯基)-3-甲基丁-3-烯-2-肟化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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形态:
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solid
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颜色:
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white to off-white
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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4-(4-氯苯基)-3-甲基丁-3-烯-2-肟性质、用途与生产工艺
AP-18 是一种选择性 TRPA1 抑制剂，AP-18 阻断 50 μM 肉桂醛对 TRPA1 的激活，在人和小鼠中的 IC50 分别为 3.1 μM 和 4.5 μM。AP-18 逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 以浓度依赖的方式减弱了 30 μM AITC 诱导的 Yo-Pro 摄取，IC50 为 10.3 μM。
At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca
2+
imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from
Xenopus oocytes
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AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity.
4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-W014421 | 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
AP-18 | 55224-94-7 | 10 mg | 1400元 |
| 2024/04/30 | HY-W014421 | 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
AP-18 | 55224-94-7 | 50 mg | 4600元 |
4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
生产厂家
55224-94-7, 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟 相关搜索:
- Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
- C11H12CINO
- 化合物AP 18
- 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
- 55224-94-7
- ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime
- 3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- 4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime
- AP-18