化合物ZL006
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- CAS号:
- 1181226-02-7
- 英文名:
- 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
- 英文别名:
- ZL006;ZL 006;ZL006;4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid;Benzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-;iGluR,Ionotropic glutamate receptors,ZL006,ZL-006,Inhibitor,inhibit,ZL 006
- 中文名:
- 化合物ZL006
- 中文别名:
- 化合物ZL006;4-((3,5-二氯-2-羟基苄基)氨基)-2-羟基苯甲酸
- CBNumber:
- CB42750480
- 分子式:
- C14H11Cl2NO4
- 分子量:
- 328.15
- MOL File:
- 1181226-02-7.mol
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化合物ZL006化学性质
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沸点:
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530.4±50.0 °C(Predicted)
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密度:
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1.617±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥5mg/mL (warmed to 60° C)
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酸度系数(pKa):
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3.40±0.10(Predicted)
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形态:
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powder
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颜色:
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white to tan
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化合物ZL006性质、用途与生产工艺
ZL006 是 nNOS/PSD-95 相互作用的抑制剂，可抑制 nMDA receptor 诱导的一氧化氮的合成。
ZL006 presents little cytotoxicity, and a growth inhibition of BCECs is not found at low concentration of 0.001, 0.01, 0.1, 1 and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is significantly enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs. ZL006 does not inhibit the nNOS-PDZ/PSD-95-PDZ interaction, or perturb the nNOS β-finger.
Compared with P-LPs/ZL006 and free ZL006, T7-P-LPs/ZL006 exhibits a significant increase of drug accumulation in the brain tissue due to its better brain targeting delivery. Compared with free ZL006, P-LPs/ZL006 and T7-P-LPs/ZL006 exhibit a significant decrease of drug accumulation in the liver and kidney.
化合物ZL006
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100456 | 化合物ZL006
ZL006 | 1181226-02-7 | 5mg | 700元 |
| 2024/04/30 | HY-100456 | 化合物ZL006
ZL006 | 1181226-02-7 | 10mM * 1mLin DMSO | 770元 |
1181226-02-7, 化合物ZL006 相关搜索:
- 4-((3,5-二氯-2-羟基苄基)氨基)-2-羟基苯甲酸
- 化合物ZL006
- 1181226-02-7
- iGluR,Ionotropic glutamate receptors,ZL006,ZL-006,Inhibitor,inhibit,ZL 006
- Benzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-
- ZL 006;ZL006
- ZL006
- 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid