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1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE
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- CAS号:
- 200626-61-5
- 英文名:
- BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
- 英文别名:
- CS-2249;ITSA-1(ITSA1);IFLAB-BB F0451-3184;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole;BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE;Methanone, 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-;inhibit,Histone deacetylases,ITSA-1,Inhibitor,HDAC,ITSA 1;(1H-Benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone
- 中文名:
- 1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE
- 中文别名:
- 化合物ITSA1;ITSA-1,HDAC激活剂;(1H-苯并[D][1,2,3]三唑-1-基)(2,4-二氯苯基)甲酮
- CBNumber:
- CB4697730
- 分子式:
- C13H7Cl2N3O
- 分子量:
- 292.12
- MOL File:
- 200626-61-5.mol
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1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE化学性质
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熔点:
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119-121°C
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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DMSO: ~28mg/mL
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形态:
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solid
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颜色:
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White to Off-White
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1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE性质、用途与生产工艺
ITSA-1 是 HDAC 的激活剂，可抵消曲古抑菌素 A (trichostatin A, TSA) 诱导的细胞周期停滞，组蛋白乙酰化和转录水平。
ITSA1 (50 μM; A549 cells) treatment serves to revert the TSA-arrested population to a normal cell cycle distribution. ITSA1 is also able to effect cell cycle rescue over longer duration.
ITSA1 (50 μM; 5 hours; A549 cells) treatment reduces the number of apoptosis in TSA-treated cells.
ITSA1 (50 μM; 2 hours; A549 and murine ES cells cells) treatment suppresses TSA-induced histone acetylation. Importantly, suppression of acetylation levels is only observable when ITSA1 is added concurrent with or post TSA treatment.
ITSA1 (50 μM; 30 minutes; murine ES cells cells) suppresses TSA-activated transcription in murine ES cells.
Cell Cycle Analysis
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Cell Line:
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Murine ES cells
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Concentration:
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50 μM
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Incubation Time:
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Result:
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Served to revert the TSA-arrested population to a normal cell cycle distribution.
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Apoptosis Analysis
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Cell Line:
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A549 cells
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Concentration:
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50 μM
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Incubation Time:
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5 hours
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Result:
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Reduced the number of apoptosis.
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Western Blot Analysis
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Cell Line:
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A549 and murine ES cells
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Concentration:
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50 μM
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Incubation Time:
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2 hours
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Result:
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Reduced histone acetylation to the baseline level.
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RT-PCR
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Cell Line:
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Murine ES cells
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Concentration:
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50 μM
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Incubation Time:
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30 minutes
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Result:
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Suppressed TSA-activated transcription.
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ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS
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mice) treatment balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling.
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Animal Model:
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CBS
+/−
mice
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Dosage:
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0.5 mg/kg
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Administration:
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Intraperitoneal injection; 3 times/week; for 8 weeks
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Result:
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Balanced deacetylation activity and suppressed IL-6 and TNF-α expression.
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1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE
上下游产品信息
上游原料
下游产品
1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE
生产厂家
200626-61-5, 1-(2,4-DICHLOROBENZOYL)-1H-BENZOTRIAZOLE 相关搜索:
- 药靶配体
- 化工试剂
- 标准品
- 活性小分子库
- DNA-RNA Transcription Regulators
- Gene Regulation and Expression
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- ITSA-1,HDAC激活剂
- (1H-苯并[D][1,2,3]三唑-1-基)(2,4-二氯苯基)甲酮
- 化合物ITSA1
- 200626-61-5
- inhibit,Histone deacetylases,ITSA-1,Inhibitor,HDAC,ITSA 1
- (1H-Benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone
- Methanone, 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-
- CS-2249
- ITSA-1(ITSA1)
- 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole
- BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
- IFLAB-BB F0451-3184