216167-92-9
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- CAS号:
- 216167-92-9
- 英文名:
- CAMOBUCOL
- 英文别名:
- CAMOBUCOL;AGIX 4207;Acetic acid,2-[4-[[1-[[3,5-bis(1,1-diMethylethyl)-4-hydroxyphenyl]thio]-1-Methylethyl]thio]-2,6-bis(1,1-diMethylethyl)phenoxy]-
- 中文名:
- 216167-92-9
- 中文别名:
- 化合物 T14861
- CBNumber:
- CB51090759
- 分子式:
- C33H50O4S2
- 分子量:
- 574.88
- MOL File:
- 216167-92-9.mol
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216167-92-9化学性质
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熔点:
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164-165 °C
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沸点:
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622.6±55.0 °C(Predicted)
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密度:
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1.11±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.23±0.10(Predicted)
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216167-92-9性质、用途与生产工艺
Camobucol (AGIX 4207) 是一种可口服的酚类抗氧化剂和抗炎剂,用于风湿病的研究。
Camobucol exhibits potent antioxidant activity toward lipid peroxides in vitro and displays enhanced cellular uptake. Camobucol selectively inhibits tumor necrosis factor (TNF)-α-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. In addition, Camobucol inhibits cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-α, IL-1β, and IL-6 from human peripheral blood mononuclear cells. Camobucol does not inhibit TNF-α-induced nuclear translocation of nuclear factor of the κ-enhancer in B cells (NF-κB), suggesting that the mechanism of action is independent of this redox-sensitive transcription factor.
216167-92-9
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-14916 | Camobucol | | 1 mg | 1818元 |
2024/04/30 | HY-14916 | 216167-92-9 Camobucol | 216167-92-9 | 5mg | 4000元 |
216167-92-9, 216167-92-9 相关搜索:
- C33H50O4S2
- 化合物 T14861
- 216167-92-9
- AGIX 4207
- Acetic acid,2-[4-[[1-[[3,5-bis(1,1-diMethylethyl)-4-hydroxyphenyl]thio]-1-Methylethyl]thio]-2,6-bis(1,1-diMethylethyl)phenoxy]-
- CAMOBUCOL