CP-547632 (hydrochloride)
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- CAS号:
- 252003-71-7
- 英文名:
- CP-547632 (hydrochloride)
- 英文别名:
- CP-547632 HYDROCHLORIDE;CP-547632 hydrochloride (PAN-90806);CP-547632 hydrochloride >=98% (HPLC);CP 547632 hydrochloride,CP547632 hydrochloride
- 中文名:
- CP-547632 (hydrochloride)
- 中文别名:
- 化合物 T10870;CP-547632盐酸盐
- CBNumber:
- CB52671229
- 分子式:
- C20H25BrClF2N5O3S
- 分子量:
- 568.86
- MOL File:
- 252003-71-7.mol
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CP-547632 (hydrochloride)化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 38.33 mg/mL (67.38 mM); Water: < 0.1 mg/mL (insoluble)
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CP-547632 (hydrochloride)性质、用途与生产工艺
CP-547632 hydrochloride 是一种口服有效的，ATP 竞争性的 VEGFR-2 和 FGF 激酶抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632 hydrochloride 对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs)。CP-547632 hydrochloride 具有抗肿瘤作用。
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VEGFR-2
11 nM (IC
50
)
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FGFR
9 nM (IC
50
)
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CP-547632 hydrochloride (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC
50
value of 6 nM.
Western Blot Analysis
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Cell Line:
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Serum-deprived cells
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Concentration:
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1, 4, 16, 63, 250, 1000 nM
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Incubation Time:
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1 hours
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Result:
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Inhibited VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion.
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CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
CP-547632 hydrochloride (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours.
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Animal Model:
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Mice bearing tumors (75-150 mm in size)
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Dosage:
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6.25, 12.5, 25, 50, 100 mg/kg
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Administration:
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P.o.; daily; 10-24 days
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Result:
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Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
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Animal Model:
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H-ras tumor-bearing mice
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Dosage:
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50 mg/kg
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Administration:
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Oral
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Result:
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A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.
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CP-547632 (hydrochloride)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13302B | CP-547632 (hydrochloride)
CP-547632 hydrochloride | 252003-71-7 | 10mM * 1mLin DMSO | 1060元 |
| 2024/04/30 | HY-13302B | CP-547632 (hydrochloride)
CP-547632 hydrochloride | 252003-71-7 | 10mg | 1250元 |
CP-547632 (hydrochloride)
生产厂家
252003-71-7, CP-547632 (hydrochloride) 相关搜索:
- 高端化学
- CP-547632盐酸盐
- 化合物 T10870
- 252003-71-7
- CP 547632 hydrochloride,CP547632 hydrochloride
- CP-547632 hydrochloride (PAN-90806)
- CP-547632 HYDROCHLORIDE
- CP-547632 hydrochloride >=98% (HPLC)