化合物SUN 11602
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- CAS号:
- 704869-38-5
- 英文名:
- SUN11602
- 英文别名:
- CS-2504;SUN11602;SUN11602;SUN11602;inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602;4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide;Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-
- 中文名:
- 化合物SUN 11602
- 中文别名:
- 化合物SUN 11602;SUN 11602,碱性成纤维细胞生长因子(BFGF)类似物
- CBNumber:
- CB52731145
- 分子式:
- C26H37N5O2
- 分子量:
- 451.60428
- MOL File:
- 704869-38-5.mol
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化合物SUN 11602化学性质
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沸点:
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679.8±55.0 °C(Predicted)
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密度:
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1.19±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: soluble
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形态:
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A crystalline solid
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酸度系数(pKa):
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16.19±0.50(Predicted)
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化合物SUN 11602性质、用途与生产工艺
SUN11602是一种新型的碱性苯胺化合物，具有成纤维细胞生长因子活性。
SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons. SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons.
In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca
2+
. This Ca
2+
-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis.
化合物SUN 11602
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101493 | SUN11602 | 704869-38-5 | 5mg | 700元 |
| 2024/04/30 | HY-101493 | SUN11602 | 704869-38-5 | 10mM * 1mLin DMSO | 770元 |
704869-38-5, 化合物SUN 11602 相关搜索:
- 药靶配体
- 生物试剂
- SUN 11602,碱性成纤维细胞生长因子(BFGF)类似物
- 化合物SUN 11602
- 704869-38-5
- Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-
- inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602
- SUN11602;SUN11602
- CS-2504
- 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide
- SUN11602