INDY
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- CAS号:
- 1169755-45-6
- 英文名:
- INDY
- 英文别名:
- INDY;(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
- 中文名:
- INDY
- 中文别名:
- 化合物INDY;化合物 T15579;INDY,DYRK1A / B抑制剂
- CBNumber:
- CB52748091
- 分子式:
- C12H13NO2S
- 分子量:
- 235.3
- MOL File:
- 1169755-45-6.mol
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INDY化学性质
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沸点:
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409.2±45.0 °C(Predicted)
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密度:
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1.337±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble5mg/mL, clear (warmed)
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酸度系数(pKa):
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9.67±0.20(Predicted)
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形态:
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powder
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颜色:
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white to beige
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INDY性质、用途与生产工艺
INDY 是一种有效，ATP 竞争性的 Dyrk1A 和 Dyrk1B 抑制剂，IC50 分别为 0.24 μM 和 0.23 μM。INDY 结合在酶的 ATP 口袋中，对 Dyrk1A 的 Ki 值为 0.18 μM。INDY 大大降低了原代胶质母细胞瘤 (GBM) 细胞系和神经祖细胞中正常细胞和致瘤细胞的自我更新能力。
IC50: 0.24 μM (Dyrk1A) and 0.23 μM (Dyrk1B)
Ki: 0.18 μM (Dyrk1A)
INDY (0.3-30 μM; 20 hours) mildly inhibits tau-phosphorylation at 3 μM, and nearly completely inhibits at 30 μM.
INDY effectively reverses the aberrant tau-phosphorylation and rescues the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) overexpression.
Western Blot Analysis
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Cell Line:
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COS7 cells transfected with either EGFP-Dyrk1A and EGFP-tau
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Concentration:
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0.3, 1, 3, 10, 30 μM
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Incubation Time:
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20 hours
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Result:
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Mildly inhibited tau-phosphorylation at 3 μM, and nearly completely inhibited at 30 μM.
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ProINDY (2.5 μM) recoveres apparently normal development of the Xenopus embryo.
INDY
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-108476 | INDY
INDY | 1169755-45-6 | 5mg | 720元 |
| 2024/04/30 | HY-108476 | INDY | | 10 mM * 1 mLin DMSO | 792元 |
1169755-45-6, INDY 相关搜索:
- 药靶配体
- INDY,DYRK1A / B抑制剂
- 化合物INDY
- 化合物 T15579
- 1169755-45-6
- (1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone
- (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
- 2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
- (Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
- (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
- INDY