STO-609
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- CAS号:
- 52029-86-4
- 英文名:
- 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
- 英文别名:
- STO-609 ACETATE;STO-609;STO-609, >98%;STO609;STO 609;STO-609 free base;STO-609 ACETIC ACID;STO-609 - CAS 52029-86-4 - Calbiochem;7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid;7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-;7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
- 中文名:
- STO-609
- 中文别名:
- 化合物STO609;STO609,CAM-KK 抑制剂;7-氧代-7H-苯并[DE]苯并[4,5]咪唑并[2,1-A]异喹啉-3-羧酸
- CBNumber:
- CB6245603
- 分子式:
- C19H10N2O3
- 分子量:
- 314.29
- MOL File:
- 52029-86-4.mol
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STO-609化学性质
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熔点:
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>300 °C
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沸点:
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716.9±62.0 °C(Predicted)
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密度:
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1.54±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: 15 mg/mL at ≥60 °C
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形态:
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solid
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酸度系数(pKa):
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2.65±0.20(Predicted)
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STO-609性质、用途与生产工艺
STO-609 是特异性的CaM-KK的抑制剂，抑制CaM-KKα和CaM-KKβ的活性，Ki值分别为80 ng/ml和15 ng/ml，并抑制其自身磷酸化活性。STO-609 可抑制 AMPKK 活性并抑制自噬。
| Target | Value |
AMPK
()
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CaM-KKβ
(Cell-free assay)
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47 nM(Ki)
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CaM-KKα
(Cell-free assay)
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0.25 μM(Ki)
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STO-609抑制重组CaM-KKα和CaM-KKβ的活性，Ki值分别为80 ng/ml和15 ng/ml，STO-609还抑制它们的自身磷酸化活性。STO-609对CaM-KK具有高度选择性，对其下游 CaM激酶(CaM-KI and -IV)没有显著作用。在转染的Hela细胞中，STO-609以剂量依赖方式抑制Ca。
对成年小鼠体内给药，STO-609会引起造骨细胞的增多、破骨细胞的减少，对卵巢切除术引发的骨质疏松症具有保护作用。脑室注射STO-609不影响对神经低血糖症的负调节反应、对低血糖引起的AMPK激活也没有影响。
用途
一种特异性的CaM-KK的抑制剂，抑制CaM-KKα和CaM-KKβ，Ki值分别为80ng/ml和15ng/ml，并抑制其自身磷酸化活性。STO-609 is a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC(50) value of the compound against CaM-KII is approximately 10 microg/ml. STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro.
STO-609
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19805 | STO-609
STO-609 | 52029-86-4 | 1mg | 400元 |
| 2024/04/30 | HY-19805 | STO-609
STO-609 | 52029-86-4 | 5mg | 800元 |
STO-609
生产厂家
全球有 82家供应商
STO-609国内生产厂家
52029-86-4, STO-609 相关搜索:
- Protein Kinase
- 合成有机化合物配体
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Calcium/Calmodulin Protein Kinase Kinase (CaMKK)
- Serine/Threonine Kinase Inhibitors
- Kinase/Phosphatase Biology
- C19H10N2O3C2H4O2
- STO609,CAM-KK 抑制剂
- 7-氧代-7H-苯并[DE]苯并[4,5]咪唑并[2,1-A]异喹啉-3-羧酸
- 化合物STO609
- 52029-86-4
- STO-609,Autophagy,AMP-activated protein kinase,AMPK,STO609,Calmodulin-dependent protein kinases,Inhibitor,Calmodulin-dependent kinases,CaMK,inhibit
- STO-609 ACETATE
- 7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-
- STO-609 free base
- STO-609 - CAS 52029-86-4 - Calbiochem
- STO609;STO 609
- STO-609, >98%
- 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
- 7H-BENZ[DE]BENZIMIDAZO[2,1-A]ISOQUINOLINE-7-ONE-3-CARBOXYLIC ACID, ACETATE
- 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid
- 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid - acetic acid
- STO-609 ACETIC ACID
- STO-609