CP 376395
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- CAS号:
- 175140-00-8
- 英文名:
- CP 376395
- 英文别名:
- CP 376395;CP 376395 hydrochloride;CP376395;CP-376395;CP 376395;4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-;N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinaminehydrochloride;inhibit,CP376395,Inhibitor,Corticotropin-releasing Factor Receptor,CRFR,CP 376395,CP-376395
- 中文名:
- CP 376395
- 中文别名:
- 化合物CP 376395
- CBNumber:
- CB62459415
- 分子式:
- C21H30N2O
- 分子量:
- 326.48
- MOL File:
- 175140-00-8.mol
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CP 376395化学性质
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熔点:
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224 °C
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沸点:
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434.9±45.0 °C(Predicted)
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密度:
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1.018±0.06 g/cm3(Predicted)
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储存条件:
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Desiccate at RT
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溶解度:
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DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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7.23±0.48(Predicted)
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CP 376395性质、用途与生产工艺
CP 376395是有效和选择性的 CRF1 受体拮抗剂。
CP 376395 fully antagonizes oCRF-stimulated adenylate cyclase activity in rat cerebral cortex and at human CRF1 receptors with an apparent K
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value of 12 nM, indicating antagonist functional activity. It is highly selective for the human CRF1 receptor subtype; affinity for the CRF2 receptor is >10000 nM. It shows affinities greater than 1 µM against 40 neurotransmitter receptor and ion channels.
In the CNS, systemically administered CP 376395 blocks the effects of both exogenous and endogenous CRF. Pretreatment with CP 376395 reverses the excitation of locus coeruleus neurons induced by icv CRF (3 µg) with an ID
50
of completely blocked the enhanced startle response induced by icv CRF (1 µg) at 17.8 mg/kg, p.o. and partially blocked at 10 mg/kg, p.o. without significantly altering baseline startle. The attenuation of fear-potentiated startle is statistically significant at lower doses (0.32-3.2 mg/kg, p.o., with 62-83% blockade) and completely reversed by CP 376395 at 10 mg/kg, p.o.
CP 376395
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-14130 | CP 376395 | | 1 mg | 545元 |
| 2024/04/30 | HY-14130 | CP 376395
CP 376395 | 175140-00-8 | 10mM * 1mLin DMSO | 1320元 |
175140-00-8, CP 376395 相关搜索:
- 合成有机化合物配体
- C21H30N2HCl
- 化合物CP 376395
- 175140-00-8
- inhibit,CP376395,Inhibitor,Corticotropin-releasing Factor Receptor,CRFR,CP 376395,CP-376395
- 4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-
- CP376395;CP-376395;CP 376395
- N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinaminehydrochloride
- CP 376395 hydrochloride
- CP 376395