192718-06-2
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- CAS号:
- 192718-06-2
- 英文名:
- 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
- 英文别名:
- C527;C527 >=98% (HPLC);2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
- 中文名:
- 192718-06-2
- 中文别名:
- 化合物C527;2-(4-氟苯基)萘并[2,3-D]恶唑-4,9-二酮
- CBNumber:
- CB62719612
- 分子式:
- C17H8FNO3
- 分子量:
- 293.25
- MOL File:
- 192718-06-2.mol
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192718-06-2化学性质
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沸点:
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488.6±47.0 °C(Predicted)
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密度:
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1.433±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO: soluble0.3mg/mL, clear (warmed)
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酸度系数(pKa):
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-4.21±0.20(Predicted)
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形态:
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powder
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颜色:
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faint yellow to dark yellow
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192718-06-2性质、用途与生产工艺
C527是泛 DUB 酶的抑制剂，对 USP1/UAF1 复合物活性较高， IC50 值为0.88 μM。
Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC
50
of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes
in vitro
. However, the IC
50
of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.
192718-06-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12988 | C527 | | 1 mg | 240元 |
| 2024/04/30 | HY-12988 | 192718-06-2
C527 | 192718-06-2 | 5mg | 600元 |
192718-06-2, 192718-06-2 相关搜索:
- 药品
- 化合物C527
- 2-(4-氟苯基)萘并[2,3-D]恶唑-4,9-二酮
- 192718-06-2
- 2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione
- Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
- C527 >=98% (HPLC)
- Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-
- C527
- 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
- 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione