EDO-S101
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- CAS号:
- 1236199-60-2
- 英文名:
- 7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide
- 英文别名:
- CS-2555;EDO-S101;Minomustine;Tinostamustine(EDO-S101);EDO-S101;EDO S101;EDOS101;EDO-S101?(Tinostamustine);Histone deacetylases,Inhibitor,EDO-S101,EDOS101,inhibit,EDO S101,HDAC,EDO-S-101;1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-;7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-hydroxyheptanamide;7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide
- 中文名:
- EDO-S101
- 中文别名:
- 化合物MINOMUSTINE;HDAC抑制剂(EDO-S101);7-(5-(双(2-氯乙基)氨基)-1-甲基-1H-苯并[D]咪唑-2-基)-N-羟基庚酰胺
- CBNumber:
- CB62735711
- 分子式:
- C19H28Cl2N4O2
- 分子量:
- 415.36
- MOL File:
- 1236199-60-2.mol
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EDO-S101化学性质
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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DMSO:14.0(Max Conc. mg/mL);33.71(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.82(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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9.48±0.20(Predicted)
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EDO-S101性质、用途与生产工艺
Tinostamustine (EDO-S101)是首批烷基化脱乙酰酶抑制剂,对I类HDACs如HDAC1, HDAC2, HDAC3和HDAC8的IC50值分别为9 nM, 9 nM, 25 nM和107 nM;而对II类HDACs如HDAC6和HDAC10的IC50值分别为6 nM和72 nM。
Target | Value |
HDAC6
(Cell-free assay)
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6 nM
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HDAC1
(Cell-free assay)
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9 nM
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HDAC2
(Cell-free assay)
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9 nM
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HDAC3
(Cell-free assay)
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25 nM
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HDAC10
(Cell-free assay)
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72 nM
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在所检测的八种骨髓瘤细胞系中,EDO-S101的IC50值范围为5-13 μM。EDO-S101与蛋白酶体抑制剂bortezomib和carfilzomib具有显著的协同细胞毒性。EDO-S101可诱导蛋白和组蛋白的乙酰化,是pIRE-1的诱导剂(pIRE-1是MM细胞中关键的UPR反应激活蛋白)。
EDO-S101
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | S8769 | EDO-S101 Tinostamustine(EDO-S101) | 1236199-60-2 | 1mg | 1040.26元 |
2024/04/30 | S8769 | EDO-S101 Tinostamustine(EDO-S101) | 1236199-60-2 | 5mg | 3497.19元 |
1236199-60-2, EDO-S101 相关搜索:
- 药靶配体
- 标准品
- 细胞生物学试剂
- 7-(5-(双(2-氯乙基)氨基)-1-甲基-1H-苯并[D]咪唑-2-基)-N-羟基庚酰胺
- 化合物MINOMUSTINE
- HDAC抑制剂(EDO-S101)
- 1236199-60-2
- EDO-S101?(Tinostamustine)
- Histone deacetylases,Inhibitor,EDO-S101,EDOS101,inhibit,EDO S101,HDAC,EDO-S-101
- 1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-
- 7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide
- 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-hydroxyheptanamide
- EDO-S101;EDO S101;EDOS101
- CS-2555
- Tinostamustine(EDO-S101)
- Minomustine
- EDO-S101
- 7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide