GSK-626616
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- CAS号:
- 1025821-33-3
- 英文名:
- GSK-626616
- 英文别名:
- GSK-626616;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- 中文名:
- GSK-626616
- 中文别名:
- 化合物GSK-626616;GSK 626616,DYRK抑制剂
- CBNumber:
- CB63303333
- 分子式:
- C18H10Cl2N4OS
- 分子量:
- 401.27
- MOL File:
- 1025821-33-3.mol
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GSK-626616化学性质
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熔点:
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281 - 282oC
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沸点:
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574.8±60.0 °C(Predicted)
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密度:
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1.55±0.1 g/cm3(Predicted)
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储存条件:
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Refrigerator, under inert atmosphere
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溶解度:
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Chloroform (Slightly, Heated), Methanol (Slightly)
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酸度系数(pKa):
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-0.94±0.20(Predicted)
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形态:
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Solid
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颜色:
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Pale Yellow to Light Yellow
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GSK-626616性质、用途与生产工艺
GSK-626616 是一种有效的口服生物可利用的 DYRK3 抑制剂，IC50为 0.7 nM。GSK-626616 以相似的效力抑制 DYRK 家族的其他成员 (例如，DYRK1A和DYRK2)，GSK-626616 可用于贫血研究。
GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired.
GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616.
GSK-626616
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-105309 | GSK-626616
GSK-626616 | 1025821-33-3 | 5mg | 1200元 |
| 2024/04/30 | HY-105309 | GSK-626616
GSK-626616 | 1025821-33-3 | 10mM * 1mLin DMSO | 1320元 |
1025821-33-3, GSK-626616 相关搜索:
- 药靶配体
- GSK 626616,DYRK抑制剂
- 化合物GSK-626616
- 1025821-33-3
- GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- 4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-
- (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
- GSK-626616