OSS-128167
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- CAS号:
- 887686-02-4
- 英文名:
- OSS-128167
- 英文别名:
- SIRT6-IN-1;OSS-128167;OSS-128167(SIRT6-IN-1);OSS-128167;OSS 128167;OSS128167;5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid;Benzoic acid, 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-;SIRT6,deacetylase,OSS_128167,TNF-α,immune,antiviral,inhibit,PPARα,H3K9,Sirtuin,acetylation,anti-cancer,Hepatitis B virus,Inhibitor,diabetes,GLUT-1,chemosensitization,HBV
- 中文名:
- OSS-128167
- 中文别名:
- 化合物OSS_128167;5-(3-(呋喃-2-甲酰胺基)苯甲酰氨基)-2-羟基苯甲酸
- CBNumber:
- CB63373071
- 分子式:
- C19H14N2O6
- 分子量:
- 366.32
- MOL File:
- 887686-02-4.mol
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OSS-128167化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO (Slightly)
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形态:
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Solid
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颜色:
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Red to Very Dark Brown
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OSS-128167性质、用途与生产工艺
OSS_128167 (SIRT6-IN-1)是一种特异性的 SIRT6 抑制剂，对SIRT6, SIRT1和SIRT2的IC50分别为89, 1578和751 μM。OSS_128167 在HBV的转录和复制中起到抗病毒的作用。
| Target | Value |
SIRT6
(Cell-free)
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89 μM
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SIRT2
(Cell-free)
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751 μM
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SIRT1
(Cell-free)
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1578 μM
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OSS-128167对SIRT6具有特异性，其对SIRT1和SIRT2的IC50s比对SIRT6的高约20倍。它具有细胞渗透性，在培养细胞中具有活性。OSS-128167能够增加H3K9乙酰化和GLUT-1的表达水平。
OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice.
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Animal Model:
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Male HBV transgenic mice (6-8-week-old)
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Dosage:
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50 mg/kg
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Administration:
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Intraperitoneal injection; every 4 days; for 12 days
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Result:
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The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.
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OSS-128167
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-107454 | OSS_128167 | | 1 mg | 454元 |
| 2024/04/30 | S8627 | OSS-128167
OSS_128167 | 887686-02-4 | 5mg | 958.86元 |
887686-02-4, OSS-128167 相关搜索:
- API
- 药靶配体
- 化合物OSS_128167
- 5-(3-(呋喃-2-甲酰胺基)苯甲酰氨基)-2-羟基苯甲酸
- 887686-02-4
- SIRT6,deacetylase,OSS_128167,TNF-α,immune,antiviral,inhibit,PPARα,H3K9,Sirtuin,acetylation,anti-cancer,Hepatitis B virus,Inhibitor,diabetes,GLUT-1,chemosensitization,HBV
- 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid
- Benzoic acid, 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-
- SIRT6-IN-1
- OSS-128167
- OSS-128167(SIRT6-IN-1)
- OSS-128167;OSS 128167;OSS128167