APT-2抑制剂
|
|
- CAS号:
- 890819-86-0
- 英文名:
- ML349
- 英文别名:
- ML349;ML349 >=98% (HPLC);ML349,Inhibitor,ML 349,inhibit,Phospholipase,ML-349;(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone;Methanone, (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-
- 中文名:
- APT-2抑制剂
- 中文别名:
- APT-2抑制剂;化合物ML349;APT-2抑制剂(ML349);ML 349,溶血磷脂酶2(LYPLA2)抑制剂
- CBNumber:
- CB63386499
- 分子式:
- C23H22N2O4S2
- 分子量:
- 454.56
- MOL File:
- 890819-86-0.mol
|
|
|
APT-2抑制剂化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 20 mg/mL (44.00 mM; Need ultrasonic)
-
|
-
形态:
-
Powder
-
|
APT-2抑制剂性质、用途与生产工艺
ML349 是一个有效且特异的酰基蛋白硫酯酶 2 (APT-2) 抑制剂,其 Ki 值为 120 nM。ML349 也是 LYPLA2 的抑制剂,其 IC50 值为 144 nM。
Ki: 120 nM (APT-2)
IC50: 144 nM (LYPLA2)
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with K
i
s of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC
50
s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.
APT-2抑制剂
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-100737 | ML349 | | 1 mg | 518元 |
2024/04/30 | HY-100737 | 890819-86-0 ML349 | 890819-86-0 | 5mg | 1140元 |
890819-86-0, APT-2抑制剂 相关搜索:
- 酶
- 细胞生物学试剂
- ML 349,溶血磷脂酶2(LYPLA2)抑制剂
- APT-2抑制剂
- 化合物ML349
- APT-2抑制剂(ML349)
- 890819-86-0
- ML349,Inhibitor,ML 349,inhibit,Phospholipase,ML-349
- ML349 >=98% (HPLC)
- Methanone, (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-
- (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
- ML349