醌霉素A
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- CAS号:
- 512-64-1
- 英文名:
- QUINOMYCIN A
- 英文别名:
- SK-302B;nsc526417;NSC 13502;ECHINOMYCIN;echinomycina;QUINOMYCIN A;Echinomycin >97%;Antibiotic A 654I;Echinomycin (NSC-13502);EchinoMycin, Actinoleukin, 1491, 59266, X 948, X 53III
- 中文名:
- 醌霉素A
- 中文别名:
- 棘霉素;醌霉素A;化合物 T15197;棘霉素HIF-1Α抑制剂
- CBNumber:
- CB6394145
- 分子式:
- C51H64N12O12S2
- 分子量:
- 1101.26
- MOL File:
- 512-64-1.mol
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醌霉素A化学性质
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熔点:
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217-218℃
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比旋光度:
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D20 -310° (c = 0.86 in chloroform)
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沸点:
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1427.2±65.0 °C(Predicted)
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密度:
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1.0964 (rough estimate)
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折射率:
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1.6700 (estimate)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (up to 5 mg/ml)
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酸度系数(pKa):
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9.38±0.70(Predicted)
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形态:
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White solid
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颜色:
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white to beige
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Merck:
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13,3531
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稳定性:
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Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
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醌霉素A性质、用途与生产工艺
Echinomycin (Quinomycin A) 是一种有效的,细胞渗透性的低氧诱导因子-1 (HIF-1) DNA 结合活性的小分子抑制剂。Echinomycin 选择性抑制癌症干细胞,其 IC50 值为 29.4 pM。
Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an
EC
50
of 1.2 nM.
RT-PCR
Cell Line:
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U251 cells
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Concentration:
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0 nM, 0.625 nM, 1.25 nM, 5 nM, 10 nM
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Incubation Time:
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16 hours
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Result:
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Significantly inhibited VEGF mRNA expression induced by hypoxia in a dose-dependent fashion.
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Echinomycin (10 μg/kg; intravenous injection; for 40 days; NOD-SCID mice) treatment efficiently eradicates mouse lymphoma and serially transplantable human acute myeloid leukemia (AML) in xenogeneic model by preferential elimination of cancer stem cells (CSCs). HIF1α maintains mouse lymphoma CSCs by repressing a negative feedback loop in the Notch pathway.
Animal Model:
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NOD-SCID mice received 1.8Gy of irradiation and i.v. injection with peripheral blood cells from patients AML-71 and AML-150
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Dosage:
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10 μg/kg
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Administration:
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Intravenous injection; for 40 days
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Result:
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Efficiently eradicated mouse lymphoma and serially transplantable human AML in xenogeneic model by preferential elimination of CSCs.
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醌霉素A
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-106101 | 醌霉素A Echinomycin | 512-64-1 | 1mg | 3600元 |
醌霉素A
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醌霉素A国内生产厂家
512-64-1, 醌霉素A 相关搜索:
- Antibiotic
- Antitumour
- 生化试剂
- 微生物代谢物
- BioChemical
- Antibiotics A to Z
- Antibiotics A-F
- Antibiotics
- C51H64N12O12S2
- 棘霉素HIF-1Α抑制剂
- 化合物 T15197
- 醌霉素A
- 棘霉素
- 512-64-1
- L-Valine, N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-, (8→1)-lactone, cyclic (3→7)-thioether
- N-[2,4,12,15,17,25-hexamethyl-29-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-7-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-20-yl]quinoxaline-2-carboxamide
- N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
- Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem
- NSC 13502
- Antibiotic A 654I
- 9,22-Dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane cyclic peptide deriv.
- EchinoMycin, Actinoleukin, 1491, 59266, X 948, X 53III
- QUINOMYCIN A
- Echinomycin (NSC-13502)
- N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester
- Echinomycin >97%
- SK-302B
- N-(2-Quinoxalinylcarbonyl)cyclo(D-Ser*-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(quinoxaline-2-ylcarbonyl)-D-Ser*-Ala-N-methyl-3-methylthio-L-Ala(1)-N-methyl-L-Val-)
- N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carbo
- ECHINOMYCIN
- nsc526417
- echinomycina