盐酸奥普力农
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- CAS号:
- 119615-63-3
- 英文名:
- OLPRINONE HYDROCHLORIDE
- 英文别名:
- e1020;Coretec;OLPRINONE HCL;xo-,monohydrochloride,monohydrate;Olprinone hydrochloride - Loprinone hydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
- 中文名:
- 盐酸奥普力农
- 中文别名:
- 盐酸奥普力农;化合物 T5033L;1,2-二氢-5-咪唑并[...
- CBNumber:
- CB6504070
- 分子式:
- C14H11ClN4O
- 分子量:
- 286.72
- MOL File:
- 119615-63-3.mol
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盐酸奥普力农化学性质
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熔点:
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>3000C
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≤4 mg/mL
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形态:
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solid
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颜色:
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beige
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盐酸奥普力农性质、用途与生产工艺
Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶 (PDE) 3 抑制剂，对 PDE1，PDE2，PDE3，PDE4 的 IC50 分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 因其正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。
Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats.
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Animal Model:
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Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)
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Dosage:
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0.2 mg/kg
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Administration:
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I.p. (administered 15 min after ischemia)
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Result:
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Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).
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119615-63-3, 盐酸奥普力农 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Heterocyclic Compounds
- 对照品
- C14H10N4OHCl
- 化合物 T5033L
- 盐酸奥普力农
- 1,2-二氢-5-咪唑并[...
- 119615-63-3
- Olprinone hydrochloride - Loprinone hydrochloride
- 3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
- Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
- Coretec
- 1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
- OLPRINONE HCL
- xo-,monohydrochloride,monohydrate
- e1020
- 3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o