腺苷5'-二磷酸核糖钠
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- CAS号:
- 68414-18-6
- 英文名:
- Adenosine 5'-diphosphoribose sodium salt
- 英文别名:
- adp-ribose;ADP ribose sodium;adenosine 5'-diphosphoribose sodium;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;Adenosine 5'-diphosphoribose sodium salt >=93%;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE;Adenosine 5′diphosphoribose sodium,Adenosine 5′ diphosphoribose sodium;[[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM
- 中文名:
- 腺苷5'-二磷酸核糖钠
- 中文别名:
- 二磷酸腺苷核糖;化合物 T10247;腺苷5'-二磷酸核糖钠;腺苷5'-二磷酸核糖钠盐;腺苷5'-二磷酸核糖钠盐
- CBNumber:
- CB6667689
- 分子式:
- C15H24N5NaO14P2
- 分子量:
- 583.32
- MOL File:
- 68414-18-6.mol
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腺苷5'-二磷酸核糖钠化学性质
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储存条件:
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-20°C
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水溶解性:
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Water : 125 mg/mL (215.04 mM)
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InChIKey:
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MBPRZUBFEMLFGQ-UUIVKEFHSA-M
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SMILES:
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O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r|
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腺苷5'-二磷酸核糖钠性质、用途与生产工艺
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物，也是一种最有效和最主要的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂，还可以增强自噬 (autophagy)。
In mouse embryonic fibroblasts (MEFs), H
2
O
2
treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca
2+
elevation through extracellular Ca
2+
influx and (or) lysosomal Ca
2+
release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca
2+
is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.
腺苷5'-二磷酸核糖钠
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100973A | 腺苷5'-二磷酸核糖钠
Adenosine 5′-diphosphoribose sodium | 68414-18-6 | 10mg | 1200元 |
| 2024/01/25 | HY-100973A | Adenosine 5′-diphosphoribose sodium | | 5 mg | 750元 |
68414-18-6, 腺苷5'-二磷酸核糖钠 相关搜索:
- 诊断检测（IVD）
- 医用原料
- 标准品
- Cofactors
- Enzymes, Inhibitors, and Substrates
- Biochemicals and Reagents
- Acyl Transfer Reagents
- BioChemical
- C15H22N5O14P2Na2H2O
- C15H22N5O14P2Na
- C15H22N5NaO14P2
- 腺苷5'-二磷酸核糖钠盐
- 腺苷5'-二磷酸核糖钠盐
- 化合物 T10247
- 二磷酸腺苷核糖
- 腺苷5'-二磷酸核糖钠
- 68414-18-6
- ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT
- Adenosine 5′diphosphoribose sodium,Adenosine 5′ diphosphoribose sodium
- ADP ribose sodium
- adp-ribose
- Adenosine 5'-diphosphoribose sodium salt >=93%
- [[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM
- ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT
- ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE
- adenosine 5'-diphosphoribose sodium
- ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE